| http://purl.uniprot.org/citations/19356801 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19356801 | http://www.w3.org/2000/01/rdf-schema#comment | "Several peripheral mechanisms appear to be operational in limiting autoimmune damage of the islets of Langerhans and organ-specific T cell-mediated autoimmunity in general. These include cyclophosphamide sensitive T regulatory cells (Treg cells) and Th2 derived cytokine downregulation. We used the model of multiple low doses of streptozotocin (MLD-STZ) induced diabetes in susceptible C57BL/6 mice and resistant BALB/c mice to study these regulatory mechanisms. We show that low dose cyclophosphamide (CY) sensitive CD4(+)CD25(+)FoxP3(+) Treg cell-dependent mechanisms can be demonstrated in C57Bl/6 mice susceptible to MLD-STZ diabetes induction. CY pretreatment decreased Foxp3(+) cell count, glycemia, glycosuria and insulitis. In contrast, CY did not overcome resistance to diabetes induction in BALB/c mice. However, in BALB/c mice, deletion of ST2, an orphan member of the IL-1R family responsible for Th2 cell signaling leads to enhanced susceptibility to diabetes induction as evaluated by level of glycemia and glycosuria, number of infiltrating cells and beta cell loss. RT-PCR analysis of mRNA transcripts of diabetogenic cytokines revealed that the expression of TNF-alpha, and IFN-gamma was significantly enhanced in pancreatic lymph nodes by day 10 after diabetes induction in ST2-deficient mice in comparison with wild type BALB/c mice while IL-17 was detected only in ST2(-/-) mice by day 21. Our results are compatible with the notion that Treg cells are involved in MLD-STZ diabetes in susceptible mice and demonstrate that ST2-mediated signaling may also be involved in limiting Th1/Th17-mediated autoimmune pathology in diabetes resistant strain."xsd:string |
| http://purl.uniprot.org/citations/19356801 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molimm.2008.12.023"xsd:string |
| http://purl.uniprot.org/citations/19356801 | http://purl.uniprot.org/core/author | "Lukic M.L."xsd:string |
| http://purl.uniprot.org/citations/19356801 | http://purl.uniprot.org/core/author | "Zdravkovic N."xsd:string |
| http://purl.uniprot.org/citations/19356801 | http://purl.uniprot.org/core/author | "Shahin A."xsd:string |
| http://purl.uniprot.org/citations/19356801 | http://purl.uniprot.org/core/author | "Arsenijevic N."xsd:string |
| http://purl.uniprot.org/citations/19356801 | http://purl.uniprot.org/core/author | "Mensah-Brown E.P."xsd:string |
| http://purl.uniprot.org/citations/19356801 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19356801 | http://purl.uniprot.org/core/name | "Mol Immunol"xsd:string |
| http://purl.uniprot.org/citations/19356801 | http://purl.uniprot.org/core/pages | "28-36"xsd:string |
| http://purl.uniprot.org/citations/19356801 | http://purl.uniprot.org/core/title | "Regulatory T cells and ST2 signaling control diabetes induction with multiple low doses of streptozotocin."xsd:string |
| http://purl.uniprot.org/citations/19356801 | http://purl.uniprot.org/core/volume | "47"xsd:string |
| http://purl.uniprot.org/citations/19356801 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19356801 |
| http://purl.uniprot.org/citations/19356801 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19356801 |
| http://purl.uniprot.org/uniprot/#_G3UYU3-mappedCitation-19356801 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19356801 |
| http://purl.uniprot.org/uniprot/#_Q3UM53-mappedCitation-19356801 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19356801 |
| http://purl.uniprot.org/uniprot/#_P14719-mappedCitation-19356801 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19356801 |
| http://purl.uniprot.org/uniprot/#_Q5D095-mappedCitation-19356801 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19356801 |
| http://purl.uniprot.org/uniprot/P14719 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19356801 |
| http://purl.uniprot.org/uniprot/Q3UM53 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19356801 |
| http://purl.uniprot.org/uniprot/Q5D095 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19356801 |
| http://purl.uniprot.org/uniprot/G3UYU3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19356801 |