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http://purl.uniprot.org/citations/19361461http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19361461http://www.w3.org/2000/01/rdf-schema#comment"

Background

We investigated if serum vascular adhesion protein-1 (SSAO/VAP-1) changed acutely following oral glucose loading and whether such changes are correlated with surrogate markers of atherosclerosis.

Methods

A total of 115 non-diabetics subjects were enrolled for an oral glucose tolerance test (OGTT). Carotid intima-medial thickness (IMT) was measured by ultrasonography. Serum SSAO/VAP-1 was analyzed by time-resolved immunofluorometric assay. Serum thiobarbituric acid reactive substances (TBARS) and advanced glycated end products (AGEs) were measured by fluorometric assays.

Results

Serum SSAO/VAP-1 increased significantly at 30 min after oral glucose loading and lasted to 2 h (p=0.0005 and p<0.0001, for 30 min and 2 h respectively). The area under curve of serum SSAO/VAP-1 during OGTT (AUC-VAP-1) correlated significantly with carotid IMT, independent of age, gender, low-density lipoprotein cholesterol, systolic blood pressure, hemoglobin A1c, serum TBARS, AGEs, and high-sensitivity C-reactive protein. Subjects with a positive AUC-VAP-1 had significantly higher serum TBARS and AGEs than subjects with a negative AUC-VAP-1 adjusted for age and gender.

Conclusions

Serum SSAO/VAP-1 changed acutely following oral glucose loading in non-diabetic subjects. Change of serum SSAO/VAP-1 correlated independently to serum TBARS, AGEs, and carotid IMT. Our findings suggest that acute change of serum SSAO/VAP-1 is a novel marker for hyperglycemia-induced atherosclerosis."xsd:string
http://purl.uniprot.org/citations/19361461http://purl.org/dc/terms/identifier"doi:10.1016/j.cca.2009.01.027"xsd:string
http://purl.uniprot.org/citations/19361461http://purl.uniprot.org/core/author"Lin C.H."xsd:string
http://purl.uniprot.org/citations/19361461http://purl.uniprot.org/core/author"Smith D.J."xsd:string
http://purl.uniprot.org/citations/19361461http://purl.uniprot.org/core/author"Wu M.Y."xsd:string
http://purl.uniprot.org/citations/19361461http://purl.uniprot.org/core/author"Lin M.S."xsd:string
http://purl.uniprot.org/citations/19361461http://purl.uniprot.org/core/author"Li H.Y."xsd:string
http://purl.uniprot.org/citations/19361461http://purl.uniprot.org/core/author"Hsu H.C."xsd:string
http://purl.uniprot.org/citations/19361461http://purl.uniprot.org/core/author"Chuang L.M."xsd:string
http://purl.uniprot.org/citations/19361461http://purl.uniprot.org/core/author"Su C.Y."xsd:string
http://purl.uniprot.org/citations/19361461http://purl.uniprot.org/core/author"Hung C.S."xsd:string
http://purl.uniprot.org/citations/19361461http://purl.uniprot.org/core/author"Chen M.F."xsd:string
http://purl.uniprot.org/citations/19361461http://purl.uniprot.org/core/author"Wei J.N."xsd:string
http://purl.uniprot.org/citations/19361461http://purl.uniprot.org/core/author"Chiang F.T."xsd:string
http://purl.uniprot.org/citations/19361461http://purl.uniprot.org/core/author"Vainio J."xsd:string
http://purl.uniprot.org/citations/19361461http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19361461http://purl.uniprot.org/core/name"Clin Chim Acta"xsd:string
http://purl.uniprot.org/citations/19361461http://purl.uniprot.org/core/pages"97-101"xsd:string
http://purl.uniprot.org/citations/19361461http://purl.uniprot.org/core/title"Change of serum vascular adhesion protein-1 after glucose loading correlates to carotid intima-medial thickness in non-diabetic subjects."xsd:string
http://purl.uniprot.org/citations/19361461http://purl.uniprot.org/core/volume"403"xsd:string
http://purl.uniprot.org/citations/19361461http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19361461
http://purl.uniprot.org/citations/19361461http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19361461
http://purl.uniprot.org/uniprot/#_Q16853-mappedCitation-19361461http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19361461
http://purl.uniprot.org/uniprot/#_Q9UEU7-mappedCitation-19361461http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19361461
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