RDF/XMLNTriplesTurtleShow queryShare
SubjectPredicateObject
http://purl.uniprot.org/citations/19362996http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19362996http://www.w3.org/2000/01/rdf-schema#comment"

Background

A hypersensitivity reaction (HSR) is associated with abacavir (ABC), a nucleoside reverse transcriptase inhibitor. Genetic association of ABC HSR with the presence of HLA-B*5701 has been demonstrated in PREDICT-1 study, showing a prevalence of 5.6% in HIV-infected population. However the prevalence of this allele in HIV-infected patients in Spain has not been established yet.

Method

This is a cross-sectional epidemiological study that included 1,198 patients in 74 centers that serve the HIV-infected population of Spain. HLA-B*5701 was checked both in the hospital lab and one central lab, showing an overall prevalence of this allele of 6%.

Results

HLA-B*5701 was most prevalent in Caucasian population (6.5%). Concordance between the local and central lab was very high for positive and negative results (95.7% and 99.3%, respectively).

Conclusion

These aspects define this test as a useful tool for the management of HIV-infected patients."xsd:string
http://purl.uniprot.org/citations/19362996http://purl.org/dc/terms/identifier"doi:10.1310/hct1001-048"xsd:string
http://purl.uniprot.org/citations/19362996http://purl.uniprot.org/core/author"Hernandez J."xsd:string
http://purl.uniprot.org/citations/19362996http://purl.uniprot.org/core/author"Rodriguez R."xsd:string
http://purl.uniprot.org/citations/19362996http://purl.uniprot.org/core/author"Martinez E."xsd:string
http://purl.uniprot.org/citations/19362996http://purl.uniprot.org/core/author"Martin T."xsd:string
http://purl.uniprot.org/citations/19362996http://purl.uniprot.org/core/author"Berenguer J."xsd:string
http://purl.uniprot.org/citations/19362996http://purl.uniprot.org/core/author"Munoz A."xsd:string
http://purl.uniprot.org/citations/19362996http://purl.uniprot.org/core/author"Gatell J.M."xsd:string
http://purl.uniprot.org/citations/19362996http://purl.uniprot.org/core/author"Knobel H."xsd:string
http://purl.uniprot.org/citations/19362996http://purl.uniprot.org/core/author"Ortega E."xsd:string
http://purl.uniprot.org/citations/19362996http://purl.uniprot.org/core/author"Munoz J."xsd:string
http://purl.uniprot.org/citations/19362996http://purl.uniprot.org/core/author"Ocampo A."xsd:string
http://purl.uniprot.org/citations/19362996http://purl.uniprot.org/core/author"Flores J."xsd:string
http://purl.uniprot.org/citations/19362996http://purl.uniprot.org/core/author"Guerrero F."xsd:string
http://purl.uniprot.org/citations/19362996http://purl.uniprot.org/core/author"Cordero M."xsd:string
http://purl.uniprot.org/citations/19362996http://purl.uniprot.org/core/author"Gutierrez F."xsd:string
http://purl.uniprot.org/citations/19362996http://purl.uniprot.org/core/author"Lozano F."xsd:string
http://purl.uniprot.org/citations/19362996http://purl.uniprot.org/core/author"Del Pozo M.A."xsd:string
http://purl.uniprot.org/citations/19362996http://purl.uniprot.org/core/author"Riera M."xsd:string
http://purl.uniprot.org/citations/19362996http://purl.uniprot.org/core/author"Rubio R."xsd:string
http://purl.uniprot.org/citations/19362996http://purl.uniprot.org/core/author"Sola J."xsd:string
http://purl.uniprot.org/citations/19362996http://purl.uniprot.org/core/author"Oteo J.A."xsd:string
http://purl.uniprot.org/citations/19362996http://purl.uniprot.org/core/author"Soriano V."xsd:string