| http://purl.uniprot.org/citations/19363159 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19363159 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19363159 | http://www.w3.org/2000/01/rdf-schema#comment | "Beta-arrestins are multifunctional adaptors that mediate the desensitization, internalization, and some signaling functions of seven-transmembrane receptors (7TMRs). Agonist-stimulated ubiquitination of beta-arrestin2 mediated by the E3 ubiquitin ligase Mdm2 is critical for rapid beta(2)-adrenergic receptor (beta(2)AR) internalization. We now report the discovery that the deubiquitinating enzyme ubiquitin-specific protease 33 (USP33) binds beta-arrestin2 and leads to the deubiquitination of beta-arrestins. USP33 and Mdm2 function reciprocally and favor respectively the stability or lability of the receptor beta-arrestin complex, thus regulating the longevity and subcellular localization of receptor signalosomes. Receptors such as the beta(2)AR, previously shown to form loose complexes with beta-arrestin ("class A") promote a beta-arrestin conformation conducive for binding to the deubiquitinase, whereas the vasopressin V2R, which forms tight beta-arrestin complexes ("class B"), promotes a distinct beta-arrestin conformation that favors dissociation of the enzyme. Thus, USP33-beta-arrestin interaction is a key regulatory step in 7TMR trafficking and signal transmission from the activated receptors to downstream effectors."xsd:string |
| http://purl.uniprot.org/citations/19363159 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0901083106"xsd:string |
| http://purl.uniprot.org/citations/19363159 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0901083106"xsd:string |
| http://purl.uniprot.org/citations/19363159 | http://purl.uniprot.org/core/author | "Lefkowitz R.J."xsd:string |
| http://purl.uniprot.org/citations/19363159 | http://purl.uniprot.org/core/author | "Lefkowitz R.J."xsd:string |
| http://purl.uniprot.org/citations/19363159 | http://purl.uniprot.org/core/author | "Shukla A.K."xsd:string |
| http://purl.uniprot.org/citations/19363159 | http://purl.uniprot.org/core/author | "Shukla A.K."xsd:string |
| http://purl.uniprot.org/citations/19363159 | http://purl.uniprot.org/core/author | "Ahn S."xsd:string |
| http://purl.uniprot.org/citations/19363159 | http://purl.uniprot.org/core/author | "Ahn S."xsd:string |
| http://purl.uniprot.org/citations/19363159 | http://purl.uniprot.org/core/author | "Berthouze M."xsd:string |
| http://purl.uniprot.org/citations/19363159 | http://purl.uniprot.org/core/author | "Berthouze M."xsd:string |
| http://purl.uniprot.org/citations/19363159 | http://purl.uniprot.org/core/author | "Miller W.E."xsd:string |
| http://purl.uniprot.org/citations/19363159 | http://purl.uniprot.org/core/author | "Miller W.E."xsd:string |
| http://purl.uniprot.org/citations/19363159 | http://purl.uniprot.org/core/author | "Shenoy S.K."xsd:string |
| http://purl.uniprot.org/citations/19363159 | http://purl.uniprot.org/core/author | "Shenoy S.K."xsd:string |
| http://purl.uniprot.org/citations/19363159 | http://purl.uniprot.org/core/author | "Xiao K."xsd:string |
| http://purl.uniprot.org/citations/19363159 | http://purl.uniprot.org/core/author | "Xiao K."xsd:string |
| http://purl.uniprot.org/citations/19363159 | http://purl.uniprot.org/core/author | "Wilkinson K.D."xsd:string |
| http://purl.uniprot.org/citations/19363159 | http://purl.uniprot.org/core/author | "Wilkinson K.D."xsd:string |
| http://purl.uniprot.org/citations/19363159 | http://purl.uniprot.org/core/author | "Modi A.S."xsd:string |
| http://purl.uniprot.org/citations/19363159 | http://purl.uniprot.org/core/author | "Modi A.S."xsd:string |
| http://purl.uniprot.org/citations/19363159 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19363159 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |