| http://purl.uniprot.org/citations/19372136 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19372136 | http://www.w3.org/2000/01/rdf-schema#comment | "Understanding intracellular signal transduction by cell surface receptors requires information about the precise order of relevant modifications on the early transducer elements. Here we introduce the B cell line DT40 and its genetically engineered variants as a model system to determine and functionally characterize post-translational protein modifications in general. This is accomplished by a customized strategy that combines mass spectrometric analyses of protein modifications with subsequent mutational studies. When applied to the B cell receptor (BCR)-proximal effector SLP-65, this approach uncovered a differential and highly dynamic engagement of numerous newly identified phospho-acceptor sites. Some of them serve as kinase substrates in resting cells and undergo rapid dephosphorylation upon BCR ligation. Stimulation-induced phosphorylation of SLP-65 can be early and transient, or early and sustained, or late. Functional elucidation of conspicuous phosphorylation at serine 170 in SLP-65 revealed a BCR-distal checkpoint for some but not all possible B cell responses. Our data show that SLP-65 phosphorylation acts upstream for signal initiation and also downstream during selective processing of the BCR signal. Such a phenomenon defines a receptor-specific signal integrator."xsd:string |
| http://purl.uniprot.org/citations/19372136 | http://purl.org/dc/terms/identifier | "doi:10.1074/mcp.m800567-mcp200"xsd:string |
| http://purl.uniprot.org/citations/19372136 | http://purl.uniprot.org/core/author | "Urlaub H."xsd:string |
| http://purl.uniprot.org/citations/19372136 | http://purl.uniprot.org/core/author | "Gronborg M."xsd:string |
| http://purl.uniprot.org/citations/19372136 | http://purl.uniprot.org/core/author | "Neumann K."xsd:string |
| http://purl.uniprot.org/citations/19372136 | http://purl.uniprot.org/core/author | "Hsiao H.H."xsd:string |
| http://purl.uniprot.org/citations/19372136 | http://purl.uniprot.org/core/author | "Wienands J."xsd:string |
| http://purl.uniprot.org/citations/19372136 | http://purl.uniprot.org/core/author | "Oellerich T."xsd:string |
| http://purl.uniprot.org/citations/19372136 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19372136 | http://purl.uniprot.org/core/name | "Mol Cell Proteomics"xsd:string |
| http://purl.uniprot.org/citations/19372136 | http://purl.uniprot.org/core/pages | "1738-1750"xsd:string |
| http://purl.uniprot.org/citations/19372136 | http://purl.uniprot.org/core/title | "SLP-65 phosphorylation dynamics reveals a functional basis for signal integration by receptor-proximal adaptor proteins."xsd:string |
| http://purl.uniprot.org/citations/19372136 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/19372136 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19372136 |
| http://purl.uniprot.org/citations/19372136 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19372136 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DH25-mappedCitation-19372136 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19372136 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DH73-mappedCitation-19372136 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19372136 |
| http://purl.uniprot.org/uniprot/#_A0A075B6P5-mappedCitation-19372136 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19372136 |
| http://purl.uniprot.org/uniprot/#_A0A075B6S6-mappedCitation-19372136 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19372136 |
| http://purl.uniprot.org/uniprot/#_P0CF74-mappedCitation-19372136 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19372136 |
| http://purl.uniprot.org/uniprot/#_P0CG04-mappedCitation-19372136 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19372136 |
| http://purl.uniprot.org/uniprot/#_Q07889-mappedCitation-19372136 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19372136 |
| http://purl.uniprot.org/uniprot/#_A2KUC3-mappedCitation-19372136 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19372136 |
| http://purl.uniprot.org/uniprot/#_A2NJV5-mappedCitation-19372136 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19372136 |