| http://purl.uniprot.org/citations/19372390 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19372390 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19372390 | http://www.w3.org/2000/01/rdf-schema#comment | "The Caenorhabditis elegans von Hippel-Lindau tumor suppressor homolog VHL-1 is a cullin E3 ubiquitin ligase that negatively regulates the hypoxic response by promoting ubiquitination and degradation of the hypoxic response transcription factor HIF-1. Here, we report that loss of VHL-1 significantly increased life span and enhanced resistance to polyglutamine and beta-amyloid toxicity. Deletion of HIF-1 was epistatic to VHL-1, indicating that HIF-1 acts downstream of VHL-1 to modulate aging and proteotoxicity. VHL-1 and HIF-1 control longevity by a mechanism distinct from both dietary restriction and insulin-like signaling. These findings define VHL-1 and the hypoxic response as an alternative longevity and protein homeostasis pathway."xsd:string |
| http://purl.uniprot.org/citations/19372390 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1173507"xsd:string |
| http://purl.uniprot.org/citations/19372390 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1173507"xsd:string |
| http://purl.uniprot.org/citations/19372390 | http://purl.uniprot.org/core/author | "Davis C."xsd:string |
| http://purl.uniprot.org/citations/19372390 | http://purl.uniprot.org/core/author | "Davis C."xsd:string |
| http://purl.uniprot.org/citations/19372390 | http://purl.uniprot.org/core/author | "Kaeberlein M."xsd:string |
| http://purl.uniprot.org/citations/19372390 | http://purl.uniprot.org/core/author | "Kaeberlein M."xsd:string |
| http://purl.uniprot.org/citations/19372390 | http://purl.uniprot.org/core/author | "Mehta R."xsd:string |
| http://purl.uniprot.org/citations/19372390 | http://purl.uniprot.org/core/author | "Mehta R."xsd:string |
| http://purl.uniprot.org/citations/19372390 | http://purl.uniprot.org/core/author | "Ramos F.J."xsd:string |
| http://purl.uniprot.org/citations/19372390 | http://purl.uniprot.org/core/author | "Ramos F.J."xsd:string |
| http://purl.uniprot.org/citations/19372390 | http://purl.uniprot.org/core/author | "Chandler-Brown D."xsd:string |
| http://purl.uniprot.org/citations/19372390 | http://purl.uniprot.org/core/author | "Chandler-Brown D."xsd:string |
| http://purl.uniprot.org/citations/19372390 | http://purl.uniprot.org/core/author | "Huh A."xsd:string |
| http://purl.uniprot.org/citations/19372390 | http://purl.uniprot.org/core/author | "Huh A."xsd:string |
| http://purl.uniprot.org/citations/19372390 | http://purl.uniprot.org/core/author | "Shamieh L.S."xsd:string |
| http://purl.uniprot.org/citations/19372390 | http://purl.uniprot.org/core/author | "Shamieh L.S."xsd:string |
| http://purl.uniprot.org/citations/19372390 | http://purl.uniprot.org/core/author | "Steinkraus K.A."xsd:string |
| http://purl.uniprot.org/citations/19372390 | http://purl.uniprot.org/core/author | "Steinkraus K.A."xsd:string |
| http://purl.uniprot.org/citations/19372390 | http://purl.uniprot.org/core/author | "Sutphin G.L."xsd:string |
| http://purl.uniprot.org/citations/19372390 | http://purl.uniprot.org/core/author | "Sutphin G.L."xsd:string |
| http://purl.uniprot.org/citations/19372390 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19372390 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |