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http://purl.uniprot.org/citations/19372458http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19372458http://www.w3.org/2000/01/rdf-schema#comment"

Objective

Core2 1 to 6-N-glucosaminyltransferase-I (C2GlcNAcT-I) plays an important role in optimizing the binding functions of several selectin ligands, including P-selectin glycoprotein ligand. We used apolipoprotein E (ApoE)-deficient atherosclerotic mice to investigate the role of C2GlcNAcT-I in platelet and leukocyte interactions with injured arterial walls, in endothelial regeneration at injured sites, and in the formation of arterial neointima.

Methods and results

Arterial neointima induced by wire injury was smaller in C2GlcNAcT-I-deficient apoE(-/-) mice than in control apoE(-/-) mice (a 79% reduction in size). Compared to controls, apoE(-/-) mice deficient in C2GlcNAcT-I also demonstrated less leukocyte adhesion on activated platelets in microflow chambers (a 75% reduction), and accumulation of leukocytes at injured areas of mouse carotid arteries was eliminated. Additionally, endothelial regeneration in injured lumenal areas was substantially faster in C2GlcNAcT-I-deficient apoE(-/-) mice than in control apoE(-/-) mice. Endothelial regeneration was associated with reduced accumulation of platelet factor 4 (PF4) at injured sites. PF4 deficiency accelerated endothelial regeneration and protected mice from neointima formation after arterial injury.

Conclusions

C2GlcNAcT-I deficiency suppresses injury-induced arterial neointima formation, and this effect is attributable to decreased leukocyte recruitment to injured vascular walls and increased endothelial regeneration. Both C2GlcNAcT-I and PF4 are promising targets for the treatment of arterial restenosis."xsd:string
http://purl.uniprot.org/citations/19372458http://purl.org/dc/terms/identifier"doi:10.1161/atvbaha.109.187716"xsd:string
http://purl.uniprot.org/citations/19372458http://purl.uniprot.org/core/author"Fukuda M."xsd:string
http://purl.uniprot.org/citations/19372458http://purl.uniprot.org/core/author"Zhang W."xsd:string
http://purl.uniprot.org/citations/19372458http://purl.uniprot.org/core/author"Zhang C."xsd:string
http://purl.uniprot.org/citations/19372458http://purl.uniprot.org/core/author"Wang H."xsd:string
http://purl.uniprot.org/citations/19372458http://purl.uniprot.org/core/author"Tang R."xsd:string
http://purl.uniprot.org/citations/19372458http://purl.uniprot.org/core/author"Zhu C."xsd:string
http://purl.uniprot.org/citations/19372458http://purl.uniprot.org/core/author"Huo Y."xsd:string
http://purl.uniprot.org/citations/19372458http://purl.uniprot.org/core/author"Marth J.D."xsd:string
http://purl.uniprot.org/citations/19372458http://purl.uniprot.org/core/author"Kowalska M.A."xsd:string
http://purl.uniprot.org/citations/19372458http://purl.uniprot.org/core/author"Hebbel R.P."xsd:string
http://purl.uniprot.org/citations/19372458http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19372458http://purl.uniprot.org/core/name"Arterioscler Thromb Vasc Biol"xsd:string
http://purl.uniprot.org/citations/19372458http://purl.uniprot.org/core/pages"1053-1059"xsd:string
http://purl.uniprot.org/citations/19372458http://purl.uniprot.org/core/title"Core2 1-6-N-glucosaminyltransferase-I deficiency protects injured arteries from neointima formation in ApoE-deficient mice."xsd:string
http://purl.uniprot.org/citations/19372458http://purl.uniprot.org/core/volume"29"xsd:string
http://purl.uniprot.org/citations/19372458http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19372458
http://purl.uniprot.org/citations/19372458http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19372458
http://purl.uniprot.org/uniprot/#_A0A0J9YTR7-mappedCitation-19372458http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19372458
http://purl.uniprot.org/uniprot/#_A0A1B0GX15-mappedCitation-19372458http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19372458
http://purl.uniprot.org/uniprot/#_G3UWN5-mappedCitation-19372458http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19372458
http://purl.uniprot.org/uniprot/#_G3UWW2-mappedCitation-19372458http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19372458
http://purl.uniprot.org/uniprot/#_G3UZM8-mappedCitation-19372458http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19372458
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