| http://purl.uniprot.org/citations/19372549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19372549 | http://www.w3.org/2000/01/rdf-schema#comment | "We aimed to gain further understanding of the molecular mechanisms involved in oxaliplatin resistance in colorectal cancer by using a proteomic approach. A 5-fold oxaliplatin-resistant cell line, HTOXAR3, was compared with its parental cell line, HT29, using two-dimensional PAGE. Mass spectrometry, Western blot, and real-time quantitative PCR confirmed the down-regulation of pyruvate kinase M2 (PK-M2) in HTOXAR3 cells. In a panel of eight colorectal cancer cell lines, we found a negative correlation between oxaliplatin resistance and PK-M2 mRNA levels (Spearman r=-0.846, P=0.008). Oxaliplatin exposure in both HT29 and HTOXAR3 led to PK-M2 mRNA up-regulation. PK-M2 mRNA levels were measured by real-time quantitative PCR in 41 tumors treated with oxaliplatin/5-fluorouracil. Tumors with the lowest PK-M2 levels attained the lowest response rates (20% versus 64.5%, P=0.026). High PK-M2 levels were associated with high p53 levels (P=0.032). In conclusion, the data provided clearly link PK-M2 expression and oxaliplatin resistance mechanisms and further implicate PK-M2 as a predictive marker of response in patients with oxaliplatin-treated colorectal cancer."xsd:string |
| http://purl.uniprot.org/citations/19372549 | http://purl.org/dc/terms/identifier | "doi:10.1158/1535-7163.mct-08-0882"xsd:string |
| http://purl.uniprot.org/citations/19372549 | http://purl.uniprot.org/core/author | "Aguilera R."xsd:string |
| http://purl.uniprot.org/citations/19372549 | http://purl.uniprot.org/core/author | "Abad A."xsd:string |
| http://purl.uniprot.org/citations/19372549 | http://purl.uniprot.org/core/author | "Neamati N."xsd:string |
| http://purl.uniprot.org/citations/19372549 | http://purl.uniprot.org/core/author | "Martinez-Cardus A."xsd:string |
| http://purl.uniprot.org/citations/19372549 | http://purl.uniprot.org/core/author | "Musulen E."xsd:string |
| http://purl.uniprot.org/citations/19372549 | http://purl.uniprot.org/core/author | "Manzano J.L."xsd:string |
| http://purl.uniprot.org/citations/19372549 | http://purl.uniprot.org/core/author | "Martinez-Balibrea E."xsd:string |
| http://purl.uniprot.org/citations/19372549 | http://purl.uniprot.org/core/author | "Gines A."xsd:string |
| http://purl.uniprot.org/citations/19372549 | http://purl.uniprot.org/core/author | "Plasencia C."xsd:string |
| http://purl.uniprot.org/citations/19372549 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19372549 | http://purl.uniprot.org/core/name | "Mol Cancer Ther"xsd:string |
| http://purl.uniprot.org/citations/19372549 | http://purl.uniprot.org/core/pages | "771-778"xsd:string |
| http://purl.uniprot.org/citations/19372549 | http://purl.uniprot.org/core/title | "A proteomic approach links decreased pyruvate kinase M2 expression to oxaliplatin resistance in patients with colorectal cancer and in human cell lines."xsd:string |
| http://purl.uniprot.org/citations/19372549 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/19372549 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19372549 |
| http://purl.uniprot.org/citations/19372549 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19372549 |
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| http://purl.uniprot.org/uniprot/#_A0A4D6DDG8-mappedCitation-19372549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19372549 |
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| http://purl.uniprot.org/uniprot/#_A0A977JB91-mappedCitation-19372549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19372549 |
| http://purl.uniprot.org/uniprot/#_B4DPM0-mappedCitation-19372549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19372549 |
| http://purl.uniprot.org/uniprot/#_Q16715-mappedCitation-19372549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19372549 |