| http://purl.uniprot.org/citations/19372587 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19372587 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19372587 | http://www.w3.org/2000/01/rdf-schema#comment | "Overexpression of the ErbB2 receptor tyrosine kinase is prevalent in approximately 30% of human breast cancers and confers Taxol resistance. Our previous work has shown that ErbB2 inhibits Taxol-induced apoptosis in breast cancer cells by transcriptionally up-regulating p21(Cip1). However, the mechanism of ErbB2-mediated p21(Cip1) up-regulation is unclear. Here, we show that ErbB2 up-regulates p21(Cip1) transcription through increased Src activity in ErbB2-overexpressing cells. Src activation further activated signal transducer and activator of transcription 3 (STAT3) that recognizes a SIE binding site on the p21(Cip1) promoter required for ErbB2-mediated p21(Cip1) transcriptional up-regulation. Both Src and STAT3 inhibitors restored Taxol sensitivity in resistant ErbB2-overexpressing breast cancer cells. Our data suggest that ErbB2 overexpression can activate STAT3 through Src leading to transcriptional up-regulation of p21(Cip1) that confers Taxol resistance of breast cancer cells. Our study suggests a potential clinical application of Src and STAT3 inhibitors in Taxol sensitization of ErbB2-overexpressing breast cancers."xsd:string |
| http://purl.uniprot.org/citations/19372587 | http://purl.org/dc/terms/identifier | "doi:10.1158/1541-7786.mcr-08-0316"xsd:string |
| http://purl.uniprot.org/citations/19372587 | http://purl.org/dc/terms/identifier | "doi:10.1158/1541-7786.mcr-08-0316"xsd:string |
| http://purl.uniprot.org/citations/19372587 | http://purl.uniprot.org/core/author | "Yu D."xsd:string |
| http://purl.uniprot.org/citations/19372587 | http://purl.uniprot.org/core/author | "Yu D."xsd:string |
| http://purl.uniprot.org/citations/19372587 | http://purl.uniprot.org/core/author | "Hung M.C."xsd:string |
| http://purl.uniprot.org/citations/19372587 | http://purl.uniprot.org/core/author | "Hung M.C."xsd:string |
| http://purl.uniprot.org/citations/19372587 | http://purl.uniprot.org/core/author | "Huang W.C."xsd:string |
| http://purl.uniprot.org/citations/19372587 | http://purl.uniprot.org/core/author | "Huang W.C."xsd:string |
| http://purl.uniprot.org/citations/19372587 | http://purl.uniprot.org/core/author | "Hawthorne V.S."xsd:string |
| http://purl.uniprot.org/citations/19372587 | http://purl.uniprot.org/core/author | "Hawthorne V.S."xsd:string |
| http://purl.uniprot.org/citations/19372587 | http://purl.uniprot.org/core/author | "Neal C.L."xsd:string |
| http://purl.uniprot.org/citations/19372587 | http://purl.uniprot.org/core/author | "Neal C.L."xsd:string |
| http://purl.uniprot.org/citations/19372587 | http://purl.uniprot.org/core/author | "Tseng L.M."xsd:string |
| http://purl.uniprot.org/citations/19372587 | http://purl.uniprot.org/core/author | "Tseng L.M."xsd:string |
| http://purl.uniprot.org/citations/19372587 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19372587 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19372587 | http://purl.uniprot.org/core/name | "Mol. Cancer Res."xsd:string |
| http://purl.uniprot.org/citations/19372587 | http://purl.uniprot.org/core/name | "Mol. Cancer Res."xsd:string |
| http://purl.uniprot.org/citations/19372587 | http://purl.uniprot.org/core/pages | "592-600"xsd:string |
| http://purl.uniprot.org/citations/19372587 | http://purl.uniprot.org/core/pages | "592-600"xsd:string |
| http://purl.uniprot.org/citations/19372587 | http://purl.uniprot.org/core/title | "ErbB2-mediated Src and signal transducer and activator of transcription 3 activation leads to transcriptional up-regulation of p21Cip1 and chemoresistance in breast cancer cells."xsd:string |
| http://purl.uniprot.org/citations/19372587 | http://purl.uniprot.org/core/title | "ErbB2-mediated Src and signal transducer and activator of transcription 3 activation leads to transcriptional up-regulation of p21Cip1 and chemoresistance in breast cancer cells."xsd:string |