http://purl.uniprot.org/citations/19374512 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/19374512 | http://www.w3.org/2000/01/rdf-schema#comment | "AimsSulfamethoxazole in combination with trimethoprim (cotrimoxazole) is used for prophylaxis and treatment of several opportunistic infections in HIV-infected patients. It is associated with a high incidence of hypersensitivity reactions, which is thought to have an immune basis. Genetic polymorphisms in MHC are known to predispose to hypersensitivity reactions to a structurally diverse group of drugs in HIV-positive patients. The aim of the study was to determine whether functional polymorphisms in TNF, LTA, HSPA1L and HLA-DRB1 genes influence the risk of cotrimoxazole hypersensitivity in HIV-infected patients.MethodsWe genotyped 136 HIV-positive patients with (n = 53) and without (n = 83) cotrimoxazole hypersensitivity using a combination of PCR-based techniques, including PCR-restriction fragment length polymorphisms, PCR-sequence specific oligonucleotides and real-time PCR. Genotypes and the haplotype frequencies were analyzed using the chi(2) test in the Haploview and CLUMP programs.ResultsNo statistically significant difference in SNP or haplotype frequencies were found in HIV-infected sulfamethoxazole hypersensitive patients compared with controls.ConclusionOur data show that MHC polymorphisms are not major predisposing factors for cotrimoxazole hypersensitivity, although we cannot exclude a minor contribution. An environmental factor (i.e., HIV infection) seems to predominate over any of the genetic factors so far investigated in increasing the risk of cotrimoxazole hypersensitivity."xsd:string |
http://purl.uniprot.org/citations/19374512 | http://purl.org/dc/terms/identifier | "doi:10.2217/pgs.09.6"xsd:string |
http://purl.uniprot.org/citations/19374512 | http://purl.uniprot.org/core/author | "Thomson W."xsd:string |
http://purl.uniprot.org/citations/19374512 | http://purl.uniprot.org/core/author | "Pirmohamed M."xsd:string |
http://purl.uniprot.org/citations/19374512 | http://purl.uniprot.org/core/author | "Park B.K."xsd:string |
http://purl.uniprot.org/citations/19374512 | http://purl.uniprot.org/core/author | "Alfirevic A."xsd:string |
http://purl.uniprot.org/citations/19374512 | http://purl.uniprot.org/core/author | "Ollier W.E."xsd:string |
http://purl.uniprot.org/citations/19374512 | http://purl.uniprot.org/core/author | "Delrieu O."xsd:string |
http://purl.uniprot.org/citations/19374512 | http://purl.uniprot.org/core/author | "Vilar F.J."xsd:string |
http://purl.uniprot.org/citations/19374512 | http://purl.uniprot.org/core/author | "Jawaid A."xsd:string |
http://purl.uniprot.org/citations/19374512 | http://purl.uniprot.org/core/author | "Bowman C.E."xsd:string |
http://purl.uniprot.org/citations/19374512 | http://purl.uniprot.org/core/author | "Alsbou M."xsd:string |
http://purl.uniprot.org/citations/19374512 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
http://purl.uniprot.org/citations/19374512 | http://purl.uniprot.org/core/name | "Pharmacogenomics"xsd:string |
http://purl.uniprot.org/citations/19374512 | http://purl.uniprot.org/core/pages | "531-540"xsd:string |
http://purl.uniprot.org/citations/19374512 | http://purl.uniprot.org/core/title | "TNF, LTA, HSPA1L and HLA-DR gene polymorphisms in HIV-positive patients with hypersensitivity to cotrimoxazole."xsd:string |
http://purl.uniprot.org/citations/19374512 | http://purl.uniprot.org/core/volume | "10"xsd:string |
http://purl.uniprot.org/citations/19374512 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19374512 |
http://purl.uniprot.org/citations/19374512 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19374512 |
http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-19374512 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19374512 |
http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-19374512 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19374512 |
http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-19374512 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19374512 |
http://purl.uniprot.org/uniprot/#_A0A0A0WDZ3-mappedCitation-19374512 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19374512 |
http://purl.uniprot.org/uniprot/#_A0A0E3DD60-mappedCitation-19374512 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19374512 |