| http://purl.uniprot.org/citations/19374888 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19374888 | http://www.w3.org/2000/01/rdf-schema#comment | "Selenium (Se), a nutritionally essential trace element with known antioxidant potential, protects the brain from oxidative damage in various models of neurodegeneration. Intracerebroventricular-streptozotocin (ICV-STZ) in rats causes impairment of brain glucose and energy metabolism along with oxidative damage and cholinergic dysfunction, and provides a relevant model for sporadic dementia of Alzheimer's type (SDAT). The present study demonstrates the therapeutic efficacy of Se on cognitive deficits and oxidative damage in ICV-STZ in rats. Male Wistar rats were pre-treated with sodium selenite, a salt of Se (0.1 mg/kg; body weight) for 7 days and then were injected bilaterally with ICV-STZ (3 mg/kg), while sham rats received the same volume of vehicle. After two ICV-STZ infusions, rats were tested for memory deficits in passive avoidance and Morris water maze (MWM) tests and then were sacrificed for biochemical and histopathological assays. ICV-STZ-infused rats showed significant loss in learning and memory ability, which were significantly improved by Se supplementation. A significant increase in thio-barbituric acid reactive species (TBARS), protein carbonyl (PC) and a significant decrease in reduced glutathione (GSH), antioxidant enzymes (glutathione peroxidase [GPx] and glutathione reductase [GR]) and adenosine triphosphate (ATP) in the hippocampus and cerebral cortex and choline acetyltransferase (ChAT) in hippocampus were observed in ICV-STZ rats. Se supplementation significantly ameliorated all alterations induced by ICV-STZ in rats. Our study reveals that Se, as a powerful antioxidant, prevents cognitive deficits, oxidative damage and morphological changes in the ICV-STZ rats. Thus, it may have a therapeutic value for the treatment of SDAT."xsd:string |
| http://purl.uniprot.org/citations/19374888 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.brainres.2009.04.010"xsd:string |
| http://purl.uniprot.org/citations/19374888 | http://purl.uniprot.org/core/author | "Khan M.M."xsd:string |
| http://purl.uniprot.org/citations/19374888 | http://purl.uniprot.org/core/author | "Yousuf S."xsd:string |
| http://purl.uniprot.org/citations/19374888 | http://purl.uniprot.org/core/author | "Khan M.B."xsd:string |
| http://purl.uniprot.org/citations/19374888 | http://purl.uniprot.org/core/author | "Ahmad A."xsd:string |
| http://purl.uniprot.org/citations/19374888 | http://purl.uniprot.org/core/author | "Islam F."xsd:string |
| http://purl.uniprot.org/citations/19374888 | http://purl.uniprot.org/core/author | "Parveen K."xsd:string |
| http://purl.uniprot.org/citations/19374888 | http://purl.uniprot.org/core/author | "Ishrat T."xsd:string |
| http://purl.uniprot.org/citations/19374888 | http://purl.uniprot.org/core/author | "Khuwaja G."xsd:string |
| http://purl.uniprot.org/citations/19374888 | http://purl.uniprot.org/core/author | "Shrivastav P."xsd:string |
| http://purl.uniprot.org/citations/19374888 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19374888 | http://purl.uniprot.org/core/name | "Brain Res"xsd:string |
| http://purl.uniprot.org/citations/19374888 | http://purl.uniprot.org/core/pages | "117-127"xsd:string |
| http://purl.uniprot.org/citations/19374888 | http://purl.uniprot.org/core/title | "Selenium prevents cognitive decline and oxidative damage in rat model of streptozotocin-induced experimental dementia of Alzheimer's type."xsd:string |
| http://purl.uniprot.org/citations/19374888 | http://purl.uniprot.org/core/volume | "1281"xsd:string |
| http://purl.uniprot.org/citations/19374888 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19374888 |
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