| http://purl.uniprot.org/citations/19375317 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19375317 | http://www.w3.org/2000/01/rdf-schema#comment | "The shelterin complex [1] shapes and protects telomeric DNA from being processed as double strand breaks (DSBs) [2, 3]. Here we show that in human undamaged cells, a fraction of the kinase Chk2, a downstream target of ATM and mediator of checkpoint responses and senescence [4, 5], physically interacts with the shelterin subunit TRF2 and colocalizes with this complex at chromosome ends. This interaction, enhanced by TRF2 binding to telomeric DNA, inhibits the activation and senescence-induced function of Chk2 by a mechanism in which TRF2 binding to the N terminus of Chk2 surrounding Thr68 hinders the phosphorylation of this priming site. In response to radiation-induced DSBs, but not chromatin-remodelling agents, the telomeric Chk2-TRF2 binding dissociates in a Chk2 activity-dependent manner. Moreover, active Chk2 phosphorylates TRF2 and decreases its binding to telomeric DNA repeats, corroborating the evidences on the specific TRF2 relocalization in presence of DSBs [6]. Altogether, the capacity of TRF2 to locally repress Chk2 provides an additional level of control by which shelterin restrains the DNA damage response from an unwanted activation [6, 7] and may explain why TRF2 overexpression acts as a telomerase-independent oncogenic stimulus [8]."xsd:string |
| http://purl.uniprot.org/citations/19375317 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2009.03.064"xsd:string |
| http://purl.uniprot.org/citations/19375317 | http://purl.uniprot.org/core/author | "Buscemi G."xsd:string |
| http://purl.uniprot.org/citations/19375317 | http://purl.uniprot.org/core/author | "Delia D."xsd:string |
| http://purl.uniprot.org/citations/19375317 | http://purl.uniprot.org/core/author | "Fontanella E."xsd:string |
| http://purl.uniprot.org/citations/19375317 | http://purl.uniprot.org/core/author | "Zannini L."xsd:string |
| http://purl.uniprot.org/citations/19375317 | http://purl.uniprot.org/core/author | "Lecis D."xsd:string |
| http://purl.uniprot.org/citations/19375317 | http://purl.uniprot.org/core/author | "Lisanti S."xsd:string |
| http://purl.uniprot.org/citations/19375317 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19375317 | http://purl.uniprot.org/core/name | "Curr Biol"xsd:string |
| http://purl.uniprot.org/citations/19375317 | http://purl.uniprot.org/core/pages | "874-879"xsd:string |
| http://purl.uniprot.org/citations/19375317 | http://purl.uniprot.org/core/title | "The shelterin protein TRF2 inhibits Chk2 activity at telomeres in the absence of DNA damage."xsd:string |
| http://purl.uniprot.org/citations/19375317 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/19375317 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19375317 |
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