| http://purl.uniprot.org/citations/19380113 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19380113 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19380113 | http://www.w3.org/2000/01/rdf-schema#comment | "Like other multicellular organisms, the model nematode C. elegans responds to infection by inducing the expression of defense genes. Among the genes upregulated in response to a natural fungal pathogen is nlp-29, encoding an antimicrobial peptide. In a screen for mutants that fail to express nlp-29 following fungal infection, we isolated alleles of tpa-1, homologous to the mammalian protein kinase C (PKC) delta. Through epistasis analyses, we demonstrate that C. elegans PKC acts through the p38 MAPK pathway to regulate nlp-29. This involves G protein signaling and specific C-type phospholipases acting upstream of PKCdelta. Unexpectedly and unlike in mammals, tpa-1 does not act via D-type protein kinases, but another C. elegans PKC gene, pkc-3, functions nonredundantly with tpa-1 to control nlp-29 expression. Finally, the tribbles-like kinase nipi-3 acts upstream of PKCdelta in this antifungal immune signaling cascade. These findings greatly expand our understanding of the pathways involved in C. elegans innate immunity."xsd:string |
| http://purl.uniprot.org/citations/19380113 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.chom.2009.03.006"xsd:string |
| http://purl.uniprot.org/citations/19380113 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.chom.2009.03.006"xsd:string |
| http://purl.uniprot.org/citations/19380113 | http://purl.uniprot.org/core/author | "Ziegler K."xsd:string |
| http://purl.uniprot.org/citations/19380113 | http://purl.uniprot.org/core/author | "Ziegler K."xsd:string |
| http://purl.uniprot.org/citations/19380113 | http://purl.uniprot.org/core/author | "Pophillat M."xsd:string |
| http://purl.uniprot.org/citations/19380113 | http://purl.uniprot.org/core/author | "Pophillat M."xsd:string |
| http://purl.uniprot.org/citations/19380113 | http://purl.uniprot.org/core/author | "Ewbank J.J."xsd:string |
| http://purl.uniprot.org/citations/19380113 | http://purl.uniprot.org/core/author | "Ewbank J.J."xsd:string |
| http://purl.uniprot.org/citations/19380113 | http://purl.uniprot.org/core/author | "Pujol N."xsd:string |
| http://purl.uniprot.org/citations/19380113 | http://purl.uniprot.org/core/author | "Pujol N."xsd:string |
| http://purl.uniprot.org/citations/19380113 | http://purl.uniprot.org/core/author | "Couillault C."xsd:string |
| http://purl.uniprot.org/citations/19380113 | http://purl.uniprot.org/core/author | "Couillault C."xsd:string |
| http://purl.uniprot.org/citations/19380113 | http://purl.uniprot.org/core/author | "Cypowyj S."xsd:string |
| http://purl.uniprot.org/citations/19380113 | http://purl.uniprot.org/core/author | "Cypowyj S."xsd:string |
| http://purl.uniprot.org/citations/19380113 | http://purl.uniprot.org/core/author | "Kurz C.L."xsd:string |
| http://purl.uniprot.org/citations/19380113 | http://purl.uniprot.org/core/author | "Kurz C.L."xsd:string |
| http://purl.uniprot.org/citations/19380113 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19380113 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19380113 | http://purl.uniprot.org/core/name | "Cell Host Microbe"xsd:string |
| http://purl.uniprot.org/citations/19380113 | http://purl.uniprot.org/core/name | "Cell Host Microbe"xsd:string |
| http://purl.uniprot.org/citations/19380113 | http://purl.uniprot.org/core/pages | "341-352"xsd:string |
| http://purl.uniprot.org/citations/19380113 | http://purl.uniprot.org/core/pages | "341-352"xsd:string |