| http://purl.uniprot.org/citations/19380743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19380743 | http://www.w3.org/2000/01/rdf-schema#comment | "The tyrosine kinase Bcr-Abl causes chronic myeloid leukemia and is the cognate target of tyrosine kinase inhibitors like imatinib. We have charted the protein-protein interaction network of Bcr-Abl by a 2-pronged approach. Using a monoclonal antibody we have first purified endogenous Bcr-Abl protein complexes from the CML K562 cell line and characterized the set of most tightly-associated interactors by MS. Nine interactors were subsequently subjected to tandem affinity purifications/MS analysis to obtain a molecular interaction network of some hundred cellular proteins. The resulting network revealed a high degree of interconnection of 7 "core" components around Bcr-Abl (Grb2, Shc1, Crk-I, c-Cbl, p85, Sts-1, and SHIP-2), and their links to different signaling pathways. Quantitative proteomics analysis showed that tyrosine kinase inhibitors lead to a disruption of this network. Certain components still appear to interact with Bcr-Abl in a phosphotyrosine-independent manner. We propose that Bcr-Abl and other drug targets, rather than being considered as single polypeptides, can be considered as complex protein assemblies that remodel upon drug action."xsd:string |
| http://purl.uniprot.org/citations/19380743 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0900653106"xsd:string |
| http://purl.uniprot.org/citations/19380743 | http://purl.uniprot.org/core/author | "Bennett K.L."xsd:string |
| http://purl.uniprot.org/citations/19380743 | http://purl.uniprot.org/core/author | "Colinge J."xsd:string |
| http://purl.uniprot.org/citations/19380743 | http://purl.uniprot.org/core/author | "Kaupe I."xsd:string |
| http://purl.uniprot.org/citations/19380743 | http://purl.uniprot.org/core/author | "Planyavsky M."xsd:string |
| http://purl.uniprot.org/citations/19380743 | http://purl.uniprot.org/core/author | "Superti-Furga G."xsd:string |
| http://purl.uniprot.org/citations/19380743 | http://purl.uniprot.org/core/author | "Hantschel O."xsd:string |
| http://purl.uniprot.org/citations/19380743 | http://purl.uniprot.org/core/author | "Mechtler K."xsd:string |
| http://purl.uniprot.org/citations/19380743 | http://purl.uniprot.org/core/author | "Brehme M."xsd:string |
| http://purl.uniprot.org/citations/19380743 | http://purl.uniprot.org/core/author | "Kocher T."xsd:string |
| http://purl.uniprot.org/citations/19380743 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19380743 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/19380743 | http://purl.uniprot.org/core/pages | "7414-7419"xsd:string |
| http://purl.uniprot.org/citations/19380743 | http://purl.uniprot.org/core/title | "Charting the molecular network of the drug target Bcr-Abl."xsd:string |
| http://purl.uniprot.org/citations/19380743 | http://purl.uniprot.org/core/volume | "106"xsd:string |
| http://purl.uniprot.org/citations/19380743 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19380743 |
| http://purl.uniprot.org/citations/19380743 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19380743 |
| http://purl.uniprot.org/uniprot/#_P63010-mappedCitation-19380743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19380743 |
| http://purl.uniprot.org/uniprot/#_Q07889-mappedCitation-19380743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19380743 |
| http://purl.uniprot.org/uniprot/#_Q07890-mappedCitation-19380743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19380743 |
| http://purl.uniprot.org/uniprot/#_Q14204-mappedCitation-19380743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19380743 |
| http://purl.uniprot.org/uniprot/#_Q14247-mappedCitation-19380743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19380743 |
| http://purl.uniprot.org/uniprot/#_Q15018-mappedCitation-19380743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19380743 |