| http://purl.uniprot.org/citations/19383348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19383348 | http://www.w3.org/2000/01/rdf-schema#comment | "We have identified differentially regulated genes in chronic myeloid leukemia (CML) cells upon short treatment with the broad-spectrum Bcr-Abl inhibitor dasatinib. The highly specific Bcr-Abl inhibitor nilotinib caused a very similar gene expression signature, validating the identified differentially regulated genes as a read-out of Bcr-Abl activity and implying that Bcr-Abl is the functionally central target of dasatinib in CML cells. Among the strongest downregulated genes, we have further validated the activation marker CD69 and the chemokine interleukin (IL)-8. Expression of both proteins is upregulated upon Bcr-Abl expression and inhibited by dasatinib and nilotinib. IL-8 may thus be a useful marker for the monitoring of CML inhibitor efficacy and play a potential pathophysiological role in CML."xsd:string |
| http://purl.uniprot.org/citations/19383348 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molonc.2008.07.003"xsd:string |
| http://purl.uniprot.org/citations/19383348 | http://purl.uniprot.org/core/author | "Burkard T.R."xsd:string |
| http://purl.uniprot.org/citations/19383348 | http://purl.uniprot.org/core/author | "Colinge J."xsd:string |
| http://purl.uniprot.org/citations/19383348 | http://purl.uniprot.org/core/author | "Kaupe I."xsd:string |
| http://purl.uniprot.org/citations/19383348 | http://purl.uniprot.org/core/author | "Superti-Furga G."xsd:string |
| http://purl.uniprot.org/citations/19383348 | http://purl.uniprot.org/core/author | "Hantschel O."xsd:string |
| http://purl.uniprot.org/citations/19383348 | http://purl.uniprot.org/core/author | "Bilban M."xsd:string |
| http://purl.uniprot.org/citations/19383348 | http://purl.uniprot.org/core/author | "Valent P."xsd:string |
| http://purl.uniprot.org/citations/19383348 | http://purl.uniprot.org/core/author | "Gstoettenbauer A."xsd:string |
| http://purl.uniprot.org/citations/19383348 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/19383348 | http://purl.uniprot.org/core/name | "Mol Oncol"xsd:string |
| http://purl.uniprot.org/citations/19383348 | http://purl.uniprot.org/core/pages | "272-281"xsd:string |
| http://purl.uniprot.org/citations/19383348 | http://purl.uniprot.org/core/title | "The chemokine interleukin-8 and the surface activation protein CD69 are markers for Bcr-Abl activity in chronic myeloid leukemia."xsd:string |
| http://purl.uniprot.org/citations/19383348 | http://purl.uniprot.org/core/volume | "2"xsd:string |
| http://purl.uniprot.org/citations/19383348 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19383348 |
| http://purl.uniprot.org/citations/19383348 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19383348 |
| http://purl.uniprot.org/uniprot/#_A0A023PX70-mappedCitation-19383348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19383348 |
| http://purl.uniprot.org/uniprot/#_A0A510LHF0-mappedCitation-19383348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19383348 |
| http://purl.uniprot.org/uniprot/#_A0A510LHH1-mappedCitation-19383348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19383348 |
| http://purl.uniprot.org/uniprot/#_A0A510LIH5-mappedCitation-19383348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19383348 |
| http://purl.uniprot.org/uniprot/#_A0A2Z5DI15-mappedCitation-19383348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19383348 |
| http://purl.uniprot.org/uniprot/#_A0A7U3S0Q4-mappedCitation-19383348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19383348 |
| http://purl.uniprot.org/uniprot/#_A0A346G3H8-mappedCitation-19383348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19383348 |