| http://purl.uniprot.org/citations/19385090 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19385090 | http://www.w3.org/2000/01/rdf-schema#comment | "Thioredoxin 1 (Trx 1) is a redox-active small protein ubiquitously present in human body. It is one of the defensive proteins induced in response to various stress conditions. In addition to its anti-oxidative effect by dithiol-disulfide exchange in its active site, Trx 1 has anti-apoptotic and anti-inflammatory effects. Trx 1 overexpression has been shown to be effective in a wide variety of animal models for oxidative and inflammatory disorders. An administration of recombinant Trx 1 protein is also effective in animal models especially for severe acute lung diseases where Trx 1 is likely to act with its anti-inflammatory properties. Trx 1 in circulation shows anti-chemotactic effects for neutrophils and inhibitory effects against macrophage migration inhibitory factor (MIF). Neovascularization is also suppressed by Trx 1 via inhibition of the complement activation. Here we discuss precise mechanisms of Trx 1 and potential therapeutic approach of this molecule."xsd:string |
| http://purl.uniprot.org/citations/19385090 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.addr.2009.01.003"xsd:string |
| http://purl.uniprot.org/citations/19385090 | http://purl.uniprot.org/core/author | "Hoshino Y."xsd:string |
| http://purl.uniprot.org/citations/19385090 | http://purl.uniprot.org/core/author | "Okuyama H."xsd:string |
| http://purl.uniprot.org/citations/19385090 | http://purl.uniprot.org/core/author | "Nakamura H."xsd:string |
| http://purl.uniprot.org/citations/19385090 | http://purl.uniprot.org/core/author | "Matsuo Y."xsd:string |
| http://purl.uniprot.org/citations/19385090 | http://purl.uniprot.org/core/author | "Yodoi J."xsd:string |
| http://purl.uniprot.org/citations/19385090 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19385090 | http://purl.uniprot.org/core/name | "Adv Drug Deliv Rev"xsd:string |
| http://purl.uniprot.org/citations/19385090 | http://purl.uniprot.org/core/pages | "303-309"xsd:string |
| http://purl.uniprot.org/citations/19385090 | http://purl.uniprot.org/core/title | "Thioredoxin 1 delivery as new therapeutics."xsd:string |
| http://purl.uniprot.org/citations/19385090 | http://purl.uniprot.org/core/volume | "61"xsd:string |
| http://purl.uniprot.org/citations/19385090 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19385090 |
| http://purl.uniprot.org/citations/19385090 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19385090 |
| http://purl.uniprot.org/uniprot/#_H9ZYJ2-mappedCitation-19385090 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19385090 |
| http://purl.uniprot.org/uniprot/#_P10599-mappedCitation-19385090 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19385090 |
| http://purl.uniprot.org/uniprot/H9ZYJ2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19385090 |
| http://purl.uniprot.org/uniprot/P10599 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19385090 |