| http://purl.uniprot.org/citations/19386265 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19386265 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19386265 | http://www.w3.org/2000/01/rdf-schema#comment | "How asymmetric divisions are connected to the terminal differentiation program of neuronal subtypes is poorly understood. In C. elegans, two homeodomain transcription factors, TTX-3 (a LHX2/9 ortholog) and CEH-10 (a CHX10 ortholog), directly activate a large battery of terminal differentiation genes in the cholinergic interneuron AIY. We establish here a transcriptional cascade linking asymmetric division to this differentiation program. A transient lineage-specific input formed by the Zic factor REF-2 and the bHLH factor HLH-2 directly activates ttx-3 expression in the AIY mother. During the terminal division of the AIY mother, an asymmetric Wnt/beta-catenin pathway cooperates with TTX-3 to directly restrict ceh-10 expression to only one of the two daughter cells. TTX-3 and CEH-10 automaintain their expression, thereby locking in the differentiation state. Our study establishes how transient lineage and asymmetric division inputs are integrated and suggests that the Wnt/beta-catenin pathway is widely used to control the identity of neuronal lineages."xsd:string |
| http://purl.uniprot.org/citations/19386265 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2009.02.011"xsd:string |
| http://purl.uniprot.org/citations/19386265 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2009.02.011"xsd:string |
| http://purl.uniprot.org/citations/19386265 | http://purl.uniprot.org/core/author | "Hobert O."xsd:string |
| http://purl.uniprot.org/citations/19386265 | http://purl.uniprot.org/core/author | "Hobert O."xsd:string |
| http://purl.uniprot.org/citations/19386265 | http://purl.uniprot.org/core/author | "Bertrand V."xsd:string |
| http://purl.uniprot.org/citations/19386265 | http://purl.uniprot.org/core/author | "Bertrand V."xsd:string |
| http://purl.uniprot.org/citations/19386265 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19386265 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19386265 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/19386265 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/19386265 | http://purl.uniprot.org/core/pages | "563-575"xsd:string |
| http://purl.uniprot.org/citations/19386265 | http://purl.uniprot.org/core/pages | "563-575"xsd:string |
| http://purl.uniprot.org/citations/19386265 | http://purl.uniprot.org/core/title | "Linking asymmetric cell division to the terminal differentiation program of postmitotic neurons in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/19386265 | http://purl.uniprot.org/core/title | "Linking asymmetric cell division to the terminal differentiation program of postmitotic neurons in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/19386265 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/19386265 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/19386265 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19386265 |
| http://purl.uniprot.org/citations/19386265 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19386265 |
| http://purl.uniprot.org/citations/19386265 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19386265 |
| http://purl.uniprot.org/citations/19386265 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19386265 |
| http://purl.uniprot.org/uniprot/G5EE86 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/19386265 |
| http://purl.uniprot.org/uniprot/Q10666 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/19386265 |