| http://purl.uniprot.org/citations/19386907 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19386907 | http://www.w3.org/2000/01/rdf-schema#comment | "We previously reported greater GABAA receptor-mediated tonic currents in D2+ striatopallidal than D1+ striatonigral medium spiny neurons (MSNs) are mediated by alpha5-subunit-containing receptors. Here, we used whole-cell recordings in slices from bacterial artificial chromosome transgenic mice to investigate the link between subunit composition, phosphorylation, and dopamine receptor activation. Whole-cell recordings in slices from delta-subunit knock-out mice demonstrate that while MSNs in wild-type mice do express delta-subunit-containing receptors, this receptor subtype is not responsible for tonic conductance observed in the acute slice preparation. We assessed the contribution of the beta1- and beta3-subunits expressed in MSNs by their sensitivity to etomidate, an agonist selective for beta2- or beta3-subunit-containing GABAA receptors. Although etomidate produced substantial tonic current in D2+ neurons, there was no effect in D1+ neurons. However, with internal PKA application or dopamine modulation, D1+ neurons expressed tonic conductance and responded to etomidate application. Our results suggest that distinct phosphorylation of beta3-subunits may cause larger tonic current in D2+ striatopallidal MSNs, and proper intracellular conditions can reveal tonic current in D1+ cells."xsd:string |
| http://purl.uniprot.org/citations/19386907 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.4737-08.2009"xsd:string |
| http://purl.uniprot.org/citations/19386907 | http://purl.uniprot.org/core/author | "Fu Z."xsd:string |
| http://purl.uniprot.org/citations/19386907 | http://purl.uniprot.org/core/author | "Vicini S."xsd:string |
| http://purl.uniprot.org/citations/19386907 | http://purl.uniprot.org/core/author | "Janssen M.J."xsd:string |
| http://purl.uniprot.org/citations/19386907 | http://purl.uniprot.org/core/author | "Ade K.K."xsd:string |
| http://purl.uniprot.org/citations/19386907 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19386907 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/19386907 | http://purl.uniprot.org/core/pages | "5116-5126"xsd:string |
| http://purl.uniprot.org/citations/19386907 | http://purl.uniprot.org/core/title | "Dopamine modulation of GABA tonic conductance in striatal output neurons."xsd:string |
| http://purl.uniprot.org/citations/19386907 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/19386907 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19386907 |
| http://purl.uniprot.org/citations/19386907 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19386907 |
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| http://purl.uniprot.org/uniprot/Q8VBV6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19386907 |
| http://purl.uniprot.org/uniprot/P22933 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19386907 |
| http://purl.uniprot.org/uniprot/Q14AH9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19386907 |