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http://purl.uniprot.org/citations/19386917 | http://www.w3.org/2000/01/rdf-schema#comment | "In a genetic screen for active zone defective mutants in Caenorhabditis elegans, we isolated a loss-of-function allele of unc-7, a gene encoding an innexin/pannexin family gap junction protein. Innexin UNC-7 regulates the size and distribution of active zones at C. elegans neuromuscular junctions. Loss-of-function mutations in another innexin, UNC-9, cause similar active zone defects as unc-7 mutants. In addition to presumptive gap junction localizations, both UNC-7 and UNC-9 are also localized perisynaptically throughout development and required in presynaptic neurons to regulate active zone differentiation. Our mosaic analyses, electron microscopy, as well as expression studies suggest a novel and likely nonjunctional role of specific innexins in active zone differentiation in addition to gap junction formations."xsd:string |
http://purl.uniprot.org/citations/19386917 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.0637-09.2009"xsd:string |
http://purl.uniprot.org/citations/19386917 | http://purl.uniprot.org/core/author | "Ng S."xsd:string |
http://purl.uniprot.org/citations/19386917 | http://purl.uniprot.org/core/author | "Kawano T."xsd:string |
http://purl.uniprot.org/citations/19386917 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
http://purl.uniprot.org/citations/19386917 | http://purl.uniprot.org/core/author | "Hung W."xsd:string |
http://purl.uniprot.org/citations/19386917 | http://purl.uniprot.org/core/author | "Zhen M."xsd:string |
http://purl.uniprot.org/citations/19386917 | http://purl.uniprot.org/core/author | "Yeh E."xsd:string |
http://purl.uniprot.org/citations/19386917 | http://purl.uniprot.org/core/author | "Fetter R."xsd:string |
http://purl.uniprot.org/citations/19386917 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
http://purl.uniprot.org/citations/19386917 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
http://purl.uniprot.org/citations/19386917 | http://purl.uniprot.org/core/pages | "5207-5217"xsd:string |
http://purl.uniprot.org/citations/19386917 | http://purl.uniprot.org/core/title | "Caenorhabditis elegans innexins regulate active zone differentiation."xsd:string |
http://purl.uniprot.org/citations/19386917 | http://purl.uniprot.org/core/volume | "29"xsd:string |
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