| http://purl.uniprot.org/citations/19387494 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19387494 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19387494 | http://www.w3.org/2000/01/rdf-schema#comment | "The nuclear factor Acinus has been suggested to mediate apoptotic chromatin condensation after caspase cleavage. However, this role has been challenged by recent observations suggesting a contribution of Acinus in apoptotic internucleosomal DNA cleavage. We report here that AAC-11, a survival protein whose expression prevents apoptosis that occurs on deprivation of growth factors, physiologically binds to Acinus and prevents Acinus-mediated DNA fragmentation. AAC-11 was able to protect Acinus from caspase-3 cleavage in vivo and in vitro, thus interfering with its biological function. Interestingly, AAC-11 depletion markedly increased cellular sensitivity to anticancer drugs, whereas its expression interfered with drug-induced cell death. AAC-11 possesses a leucine-zipper domain that dictates, upon oligomerization, its interaction with Acinus as well as the antiapoptotic effect of AAC-11 on drug-induced cell death. A cell permeable peptide that mimics the leucine-zipper subdomain of AAC-11, thus preventing its oligomerization, inhibited the AAC-11-Acinus complex formation and potentiated drug-mediated apoptosis in cancer cells. Our results, therefore, show that targeting AAC-11 might be a potent strategy for cancer treatment by sensitization of tumour cells to chemotherapeutic drugs."xsd:string |
| http://purl.uniprot.org/citations/19387494 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2009.106"xsd:string |
| http://purl.uniprot.org/citations/19387494 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2009.106"xsd:string |
| http://purl.uniprot.org/citations/19387494 | http://purl.uniprot.org/core/author | "Rain J.-C."xsd:string |
| http://purl.uniprot.org/citations/19387494 | http://purl.uniprot.org/core/author | "Rain J.-C."xsd:string |
| http://purl.uniprot.org/citations/19387494 | http://purl.uniprot.org/core/author | "Calvo F."xsd:string |
| http://purl.uniprot.org/citations/19387494 | http://purl.uniprot.org/core/author | "Calvo F."xsd:string |
| http://purl.uniprot.org/citations/19387494 | http://purl.uniprot.org/core/author | "Faye A."xsd:string |
| http://purl.uniprot.org/citations/19387494 | http://purl.uniprot.org/core/author | "Faye A."xsd:string |
| http://purl.uniprot.org/citations/19387494 | http://purl.uniprot.org/core/author | "Michel L."xsd:string |
| http://purl.uniprot.org/citations/19387494 | http://purl.uniprot.org/core/author | "Michel L."xsd:string |
| http://purl.uniprot.org/citations/19387494 | http://purl.uniprot.org/core/author | "Piddubnyak V."xsd:string |
| http://purl.uniprot.org/citations/19387494 | http://purl.uniprot.org/core/author | "Piddubnyak V."xsd:string |
| http://purl.uniprot.org/citations/19387494 | http://purl.uniprot.org/core/author | "Poyet J.-L."xsd:string |
| http://purl.uniprot.org/citations/19387494 | http://purl.uniprot.org/core/author | "Poyet J.-L."xsd:string |
| http://purl.uniprot.org/citations/19387494 | http://purl.uniprot.org/core/author | "Rigou P."xsd:string |
| http://purl.uniprot.org/citations/19387494 | http://purl.uniprot.org/core/author | "Rigou P."xsd:string |
| http://purl.uniprot.org/citations/19387494 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19387494 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19387494 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/19387494 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/19387494 | http://purl.uniprot.org/core/pages | "1576-1588"xsd:string |
| http://purl.uniprot.org/citations/19387494 | http://purl.uniprot.org/core/pages | "1576-1588"xsd:string |