| http://purl.uniprot.org/citations/19389128 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19389128 | http://www.w3.org/2000/01/rdf-schema#comment | "Listeriolysin O (LLO) is a thiol-activated cytolysin secreted by Listeria monocytogenes. LLO and phosphatidylinositol phospholipase C are two essential virulence factors, which this bacterium needs to escape from the phagosomal compartment to the cytoplasm. Cathepsin-D specifically cleaves LLO, between the Trp-491 (tryptophan amino acid in three letter nomenclature) and Trp-492 residues of the conserved undecapeptide sequence, ECTGLAWEWWR, in the domain 4 of LLO (D4). Moreover, these residues also correspond to the phagosomal-binding epitope. Cathepsin-D had no effect on phosphatidylinositol phospholipase C. We have observed that cathepsin-D cleaved the related cholesterol-dependent cytolysin pneumolysin at the same undecapeptide sequence between Trp-435 and Trp-436 residues. These studies also revealed an additional cathepsin-D cleavage site in the pneumolysin D4 domain localized in the 361-GDLLLD-366 sequence. These differences might confer a pathogenic advantage to listeriolysin O, increasing its resistance to phagosomal cathepsin-D action by reducing the number of cleavages sites in the D4 domain. Using ΔLLO/W491A and ΔLLO/W492A bacterial mutants, we reveal that the Trp-491 residue has an important role linked to cathepsin-D in Listeria innate immunity."xsd:string |
| http://purl.uniprot.org/citations/19389128 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2958.2009.06673.x"xsd:string |
| http://purl.uniprot.org/citations/19389128 | http://purl.uniprot.org/core/author | "Chen W."xsd:string |
| http://purl.uniprot.org/citations/19389128 | http://purl.uniprot.org/core/author | "Albar J.P."xsd:string |
| http://purl.uniprot.org/citations/19389128 | http://purl.uniprot.org/core/author | "Paradela A."xsd:string |
| http://purl.uniprot.org/citations/19389128 | http://purl.uniprot.org/core/author | "Tobes R."xsd:string |
| http://purl.uniprot.org/citations/19389128 | http://purl.uniprot.org/core/author | "Carrasco-Marin E."xsd:string |
| http://purl.uniprot.org/citations/19389128 | http://purl.uniprot.org/core/author | "Pareja E."xsd:string |
| http://purl.uniprot.org/citations/19389128 | http://purl.uniprot.org/core/author | "Alvarez-Dominguez C."xsd:string |
| http://purl.uniprot.org/citations/19389128 | http://purl.uniprot.org/core/author | "Madrazo-Toca F."xsd:string |
| http://purl.uniprot.org/citations/19389128 | http://purl.uniprot.org/core/author | "Cacho-Alonso E."xsd:string |
| http://purl.uniprot.org/citations/19389128 | http://purl.uniprot.org/core/author | "Gomez-Lopez M.T."xsd:string |
| http://purl.uniprot.org/citations/19389128 | http://purl.uniprot.org/core/author | "de los Toyos J.R."xsd:string |
| http://purl.uniprot.org/citations/19389128 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19389128 | http://purl.uniprot.org/core/name | "Mol Microbiol"xsd:string |
| http://purl.uniprot.org/citations/19389128 | http://purl.uniprot.org/core/pages | "668-682"xsd:string |
| http://purl.uniprot.org/citations/19389128 | http://purl.uniprot.org/core/title | "The innate immunity role of cathepsin-D is linked to Trp-491 and Trp-492 residues of listeriolysin O."xsd:string |
| http://purl.uniprot.org/citations/19389128 | http://purl.uniprot.org/core/volume | "72"xsd:string |
| http://purl.uniprot.org/citations/19389128 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19389128 |
| http://purl.uniprot.org/citations/19389128 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19389128 |
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| http://purl.uniprot.org/uniprot/#_P07339-mappedCitation-19389128 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19389128 |
| http://purl.uniprot.org/uniprot/P13128 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19389128 |
| http://purl.uniprot.org/uniprot/P07339 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19389128 |