| http://purl.uniprot.org/citations/19389701 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19389701 | http://www.w3.org/2000/01/rdf-schema#comment | "How transcription factors interpret the output from signal transduction pathways to drive distinct programs of gene expression is a key issue that underpins development and disease. The ubiquitously expressed basic-helix-loop-helix leucine zipper upstream stimulating factor-1 binds E-box regulatory elements (CANNTG) to regulate a wide number of gene networks. In particular, USF-1 is a key component of the tanning process. Following UV irradiation, USF-1 is phosphorylated by the p38 stress-activated kinase on threonine 153 and directly up-regulates expression of the POMC, MC1R, TYR, TYRP-1 and DCT genes. However, how phosphorylation on Thr-153 might affect the activity of USF-1 is unclear. Here we show that, in response to DNA damage, oxidative stress and cellular infection USF-1 is acetylated in a phospho-Thr-153-dependent fashion. Phospho-acetylated USF-1 is nuclear and interacts with DNA but displays altered gene regulatory properties. Phospho-acetylated USF-1 is thus proposed to be associated with loss of transcriptional activation properties toward several target genes implicated in pigmentation process and cell cycle regulation. The identification of this critical stress-dependent USF-1 modification gives new insights into understanding USF-1 gene expression modulation associated with cancer development."xsd:string |
| http://purl.uniprot.org/citations/19389701 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m808605200"xsd:string |
| http://purl.uniprot.org/citations/19389701 | http://purl.uniprot.org/core/author | "Le Seyec J."xsd:string |
| http://purl.uniprot.org/citations/19389701 | http://purl.uniprot.org/core/author | "Goding C."xsd:string |
| http://purl.uniprot.org/citations/19389701 | http://purl.uniprot.org/core/author | "Galibert M.D."xsd:string |
| http://purl.uniprot.org/citations/19389701 | http://purl.uniprot.org/core/author | "Primot A."xsd:string |
| http://purl.uniprot.org/citations/19389701 | http://purl.uniprot.org/core/author | "Corre S."xsd:string |
| http://purl.uniprot.org/citations/19389701 | http://purl.uniprot.org/core/author | "Baron Y."xsd:string |
| http://purl.uniprot.org/citations/19389701 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19389701 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/19389701 | http://purl.uniprot.org/core/pages | "18851-18862"xsd:string |
| http://purl.uniprot.org/citations/19389701 | http://purl.uniprot.org/core/title | "Target gene specificity of USF-1 is directed via p38-mediated phosphorylation-dependent acetylation."xsd:string |
| http://purl.uniprot.org/citations/19389701 | http://purl.uniprot.org/core/volume | "284"xsd:string |
| http://purl.uniprot.org/citations/19389701 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19389701 |
| http://purl.uniprot.org/citations/19389701 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19389701 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4U5-mappedCitation-19389701 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19389701 |
| http://purl.uniprot.org/uniprot/#_E9PJ52-mappedCitation-19389701 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19389701 |
| http://purl.uniprot.org/uniprot/#_A0A510GDE6-mappedCitation-19389701 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19389701 |
| http://purl.uniprot.org/uniprot/#_A0A7H1D2R2-mappedCitation-19389701 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19389701 |
| http://purl.uniprot.org/uniprot/#_A0A7H1D2R4-mappedCitation-19389701 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19389701 |
| http://purl.uniprot.org/uniprot/#_A0A7H1D2R5-mappedCitation-19389701 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19389701 |
| http://purl.uniprot.org/uniprot/#_A0A7H1D2R6-mappedCitation-19389701 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19389701 |
| http://purl.uniprot.org/uniprot/#_A0A7H1D2S6-mappedCitation-19389701 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19389701 |
| http://purl.uniprot.org/uniprot/#_B1AQP1-mappedCitation-19389701 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19389701 |