| http://purl.uniprot.org/citations/19389931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19389931 | http://www.w3.org/2000/01/rdf-schema#comment | "Prominent eosinophil infiltration is a characteristic of some forms of vasculitis, such as Churg-Strauss syndrome, also known as allergic granulomatous vasculitis. In the current study, we established a mouse model of cutaneous eosinophilic vasculitis by the cutaneous reverse passive Arthus reaction using IgE injection instead of IgG. Wild-type C57BL/6 mice were injected with IgE anti-trinitrophenyl antibodies, followed immediately by intravenous administration of trinitrophenyl bovine serum albumin. IgE-mediated immune complex challenge induced substantial hemorrhage with marked infiltration of eosinophils in which neutrophils, mast cells, and macrophages were also mixed. This finding contrasted remarkably with the neutrophil-dominant infiltration pattern in IgG-mediated immune complex challenge. In the lesion, the expression level of monocyte chemotactic protein-3 was increased, and anti-monocyte chemotactic protein-3 treatment resulted in a significant but incomplete blockade of eosinophil recruitment. Furthermore, mice lacking E-selectin, P-selectin, L-selectin, or intercellular adhesion molecule-1, as well as wild-type mice that received anti-vascular cell adhesion molecule-1-blocking antibodies were assessed for the IgE-mediated Arthus reaction. After 24 hours, the loss of P-selectin resulted in a significant reduction in eosinophil accumulation compared with both wild-type mice and other mouse mutants. Collectively, the Fc class of immunoglobulins, which forms these immune complexes, critically determines the disease manifestation of vasculitis. The IgE-mediated cutaneous reverse passive Arthus reaction may serve as an experimental model for cutaneous eosinophilic infiltration in vasculitis as well as in other diseases."xsd:string |
| http://purl.uniprot.org/citations/19389931 | http://purl.org/dc/terms/identifier | "doi:10.2353/ajpath.2009.080223"xsd:string |
| http://purl.uniprot.org/citations/19389931 | http://purl.uniprot.org/core/author | "Hasegawa M."xsd:string |
| http://purl.uniprot.org/citations/19389931 | http://purl.uniprot.org/core/author | "Fujita T."xsd:string |
| http://purl.uniprot.org/citations/19389931 | http://purl.uniprot.org/core/author | "Shimizu K."xsd:string |
| http://purl.uniprot.org/citations/19389931 | http://purl.uniprot.org/core/author | "Sato S."xsd:string |
| http://purl.uniprot.org/citations/19389931 | http://purl.uniprot.org/core/author | "Tedder T.F."xsd:string |
| http://purl.uniprot.org/citations/19389931 | http://purl.uniprot.org/core/author | "Ishii T."xsd:string |
| http://purl.uniprot.org/citations/19389931 | http://purl.uniprot.org/core/author | "Fujimoto M."xsd:string |
| http://purl.uniprot.org/citations/19389931 | http://purl.uniprot.org/core/author | "Nakashima H."xsd:string |
| http://purl.uniprot.org/citations/19389931 | http://purl.uniprot.org/core/author | "Matsushita T."xsd:string |
| http://purl.uniprot.org/citations/19389931 | http://purl.uniprot.org/core/author | "Takehara K."xsd:string |
| http://purl.uniprot.org/citations/19389931 | http://purl.uniprot.org/core/author | "Yanaba K."xsd:string |
| http://purl.uniprot.org/citations/19389931 | http://purl.uniprot.org/core/author | "Ogawa F."xsd:string |
| http://purl.uniprot.org/citations/19389931 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19389931 | http://purl.uniprot.org/core/name | "Am J Pathol"xsd:string |
| http://purl.uniprot.org/citations/19389931 | http://purl.uniprot.org/core/pages | "2225-2233"xsd:string |
| http://purl.uniprot.org/citations/19389931 | http://purl.uniprot.org/core/title | "Establishment of experimental eosinophilic vasculitis by IgE-mediated cutaneous reverse passive arthus reaction."xsd:string |
| http://purl.uniprot.org/citations/19389931 | http://purl.uniprot.org/core/volume | "174"xsd:string |
| http://purl.uniprot.org/citations/19389931 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19389931 |
| http://purl.uniprot.org/citations/19389931 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19389931 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YW25-mappedCitation-19389931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19389931 |
| http://purl.uniprot.org/uniprot/#_B1B506-mappedCitation-19389931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19389931 |
| http://purl.uniprot.org/uniprot/#_B1B507-mappedCitation-19389931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19389931 |