http://purl.uniprot.org/citations/19398759 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/19398759 | http://www.w3.org/2000/01/rdf-schema#comment | "Centromeres are chromosomal structures required for equal DNA segregation to daughter cells, comprising specialized nucleosomes containing centromere protein A (CENP-A) histone, which provide the basis for centromeric chromatin assembly. Discovery of centromere protein components is progressing, but knowledge related to their establishment and maintenance remains limited. Previously, using anti-CENP-A native chromatin immunoprecipitation, we isolated the interphase-centromere complex (ICEN). Among ICEN components, subunits of the remodeling and spacing factor (RSF) complex, Rsf-1 and SNF2h proteins, were found. This paper describes the relationship of the RSF complex to centromere structure and function, demonstrating its requirement for maintenance of CENP-A at the centromeric core chromatin in HeLa cells. The RSF complex interacted with CENP-A chromatin in mid-G1. Rsf-1 depletion induced loss of centromeric CENP-A, and purified RSF complex reconstituted and spaced CENP-A nucleosomes in vitro. From these data, we propose the RSF complex as a new factor actively supporting the assembly of CENP-A chromatin."xsd:string |
http://purl.uniprot.org/citations/19398759 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200903088"xsd:string |
http://purl.uniprot.org/citations/19398759 | http://purl.uniprot.org/core/author | "Yang H."xsd:string |
http://purl.uniprot.org/citations/19398759 | http://purl.uniprot.org/core/author | "Yoda K."xsd:string |
http://purl.uniprot.org/citations/19398759 | http://purl.uniprot.org/core/author | "Nozaki N."xsd:string |
http://purl.uniprot.org/citations/19398759 | http://purl.uniprot.org/core/author | "Obuse C."xsd:string |
http://purl.uniprot.org/citations/19398759 | http://purl.uniprot.org/core/author | "Perpelescu M."xsd:string |
http://purl.uniprot.org/citations/19398759 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
http://purl.uniprot.org/citations/19398759 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
http://purl.uniprot.org/citations/19398759 | http://purl.uniprot.org/core/pages | "397-407"xsd:string |
http://purl.uniprot.org/citations/19398759 | http://purl.uniprot.org/core/title | "Active establishment of centromeric CENP-A chromatin by RSF complex."xsd:string |
http://purl.uniprot.org/citations/19398759 | http://purl.uniprot.org/core/volume | "185"xsd:string |
http://purl.uniprot.org/citations/19398759 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19398759 |
http://purl.uniprot.org/citations/19398759 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19398759 |
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