| http://purl.uniprot.org/citations/19401191 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19401191 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin (IL)-9 is associated with key pathological features of asthma such as airway hyperresponsiveness, bronchoconstriction and mucus production. Inflammatory responses mediated by IL-9 rely on the expression of the IL-9R which has been reported on lung epithelial cells, T lymphocytes and recently on airway granulocyte infiltrates. In this study, we assessed the regulatory and constitutive cell surface expression of the IL-9Ralpha in unfractionated and purified human neutrophils from atopic asthmatics, atopic non-asthmatics and healthy normal controls. We demonstrate that T(H)2 cytokines (IL-4 or IL-13) and granulocyte macrophage-colony stimulating factor (GM-CSF) up-regulated mRNA and cell surface expression levels of the IL-9Ralpha in primary human and HL-60 differentiated neutrophils. Pharmacological inhibition of NF-kappaB did not affect T(H)2-mediated IL-9Ralpha expression in human neutrophils although IFN-gamma and IL-10 down-regulated IL-9Ralpha expression when co-incubated with IL-4, IL-13 or GM-CSF. Collectively, our results reveal a regulatory function for IFN-gamma and IL-10 on modulating the inducible IL-9Ralpha expression levels on peripheral blood neutrophils by T(H)2 cytokines."xsd:string |
| http://purl.uniprot.org/citations/19401191 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2009.04.104"xsd:string |
| http://purl.uniprot.org/citations/19401191 | http://purl.uniprot.org/core/author | "Dragon S."xsd:string |
| http://purl.uniprot.org/citations/19401191 | http://purl.uniprot.org/core/author | "Shan L."xsd:string |
| http://purl.uniprot.org/citations/19401191 | http://purl.uniprot.org/core/author | "Simons F.E."xsd:string |
| http://purl.uniprot.org/citations/19401191 | http://purl.uniprot.org/core/author | "Hayglass K.T."xsd:string |
| http://purl.uniprot.org/citations/19401191 | http://purl.uniprot.org/core/author | "Gounni A.S."xsd:string |
| http://purl.uniprot.org/citations/19401191 | http://purl.uniprot.org/core/author | "Takhar M.K."xsd:string |
| http://purl.uniprot.org/citations/19401191 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19401191 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/19401191 | http://purl.uniprot.org/core/pages | "167-172"xsd:string |
| http://purl.uniprot.org/citations/19401191 | http://purl.uniprot.org/core/title | "T(H)2 cytokines modulate the IL-9R expression on human neutrophils."xsd:string |
| http://purl.uniprot.org/citations/19401191 | http://purl.uniprot.org/core/volume | "384"xsd:string |
| http://purl.uniprot.org/citations/19401191 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19401191 |
| http://purl.uniprot.org/citations/19401191 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19401191 |
| http://purl.uniprot.org/uniprot/#_B4E011-mappedCitation-19401191 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19401191 |
| http://purl.uniprot.org/uniprot/#_I6L9D8-mappedCitation-19401191 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19401191 |
| http://purl.uniprot.org/uniprot/#_Q01113-mappedCitation-19401191 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19401191 |
| http://purl.uniprot.org/uniprot/Q01113 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19401191 |
| http://purl.uniprot.org/uniprot/I6L9D8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19401191 |
| http://purl.uniprot.org/uniprot/B4E011 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19401191 |