| http://purl.uniprot.org/citations/19404407 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19404407 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19404407 | http://www.w3.org/2000/01/rdf-schema#comment | "TNF-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family that participates in HIV-1 pathogenesis through the depletion of CD4+ T cells. TRAIL is expressed on the cell membrane of peripheral immune cells and can be cleaved into a soluble, secreted form. The regulation of TRAIL in macrophages during HIV-1 infection is not completely understood. In this study, we investigated the mechanism(s) of TRAIL expression in HIV-1-infected macrophages, an important cell type in HIV-1 pathogenesis. A human monocyte-derived macrophage (MDM) culture system was infected with macrophage-tropic HIV-1(ADA), HIV-1(JR-FL), or HIV-1(BAL) strains. TRAIL, predominantly the membrane-bound form, increased following HIV-1 infection. We found that HIV-1 infection also induced interferon regulatory factor (IRF)-1, IRF-7 gene expression and signal transducers and activators of transcription 1 (STAT1) activation. Small interfering RNA knockdown of IRF-1 or IRF-7, but not IRF-3, reduced STAT1 activation and TRAIL expression. Furthermore, the upregulation of IRF-1, IRF-7, TRAIL, and the activation of STAT1 by HIV-1 infection was reduced by the treatment of type I interferon (IFN)-neutralizing antibodies. In addition, inhibition of STAT1 by fludarabine abolished IRF-1, IRF-7, and TRAIL upregulation. We conclude that IRF-1, IRF-7, type I IFNs, and STAT1 form a signaling feedback loop that is critical in regulating TRAIL expression in HIV-1-infected macrophages."xsd:string |
| http://purl.uniprot.org/citations/19404407 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0005397"xsd:string |
| http://purl.uniprot.org/citations/19404407 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0005397"xsd:string |
| http://purl.uniprot.org/citations/19404407 | http://purl.uniprot.org/core/author | "Huang Y."xsd:string |
| http://purl.uniprot.org/citations/19404407 | http://purl.uniprot.org/core/author | "Huang Y."xsd:string |
| http://purl.uniprot.org/citations/19404407 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/19404407 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/19404407 | http://purl.uniprot.org/core/author | "Zhao Y."xsd:string |
| http://purl.uniprot.org/citations/19404407 | http://purl.uniprot.org/core/author | "Zhao Y."xsd:string |
| http://purl.uniprot.org/citations/19404407 | http://purl.uniprot.org/core/author | "Ye L."xsd:string |
| http://purl.uniprot.org/citations/19404407 | http://purl.uniprot.org/core/author | "Ye L."xsd:string |
| http://purl.uniprot.org/citations/19404407 | http://purl.uniprot.org/core/author | "Cui M."xsd:string |
| http://purl.uniprot.org/citations/19404407 | http://purl.uniprot.org/core/author | "Cui M."xsd:string |
| http://purl.uniprot.org/citations/19404407 | http://purl.uniprot.org/core/author | "Walstrom A."xsd:string |
| http://purl.uniprot.org/citations/19404407 | http://purl.uniprot.org/core/author | "Walstrom A."xsd:string |
| http://purl.uniprot.org/citations/19404407 | http://purl.uniprot.org/core/author | "Zheng J.C."xsd:string |
| http://purl.uniprot.org/citations/19404407 | http://purl.uniprot.org/core/author | "Zheng J.C."xsd:string |
| http://purl.uniprot.org/citations/19404407 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19404407 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19404407 | http://purl.uniprot.org/core/name | "PLoS ONE"xsd:string |
| http://purl.uniprot.org/citations/19404407 | http://purl.uniprot.org/core/name | "PLoS ONE"xsd:string |
| http://purl.uniprot.org/citations/19404407 | http://purl.uniprot.org/core/pages | "E5397"xsd:string |
| http://purl.uniprot.org/citations/19404407 | http://purl.uniprot.org/core/pages | "E5397"xsd:string |