| http://purl.uniprot.org/citations/19407142 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19407142 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19407142 | http://www.w3.org/2000/01/rdf-schema#comment | "Type 2C protein phosphatases (PP2Cs) are vitally involved in abscisic acid (ABA) signaling. Here, we show that a synthetic growth inhibitor called pyrabactin functions as a selective ABA agonist. Pyrabactin acts through PYRABACTIN RESISTANCE 1 (PYR1), the founding member of a family of START proteins called PYR/PYLs, which are necessary for both pyrabactin and ABA signaling in vivo. We show that ABA binds to PYR1, which in turn binds to and inhibits PP2Cs. We conclude that PYR/PYLs are ABA receptors functioning at the apex of a negative regulatory pathway that controls ABA signaling by inhibiting PP2Cs. Our results illustrate the power of the chemical genetic approach for sidestepping genetic redundancy."xsd:string |
| http://purl.uniprot.org/citations/19407142 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1173041"xsd:string |
| http://purl.uniprot.org/citations/19407142 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1173041"xsd:string |
| http://purl.uniprot.org/citations/19407142 | http://purl.uniprot.org/core/author | "Park S.-Y."xsd:string |
| http://purl.uniprot.org/citations/19407142 | http://purl.uniprot.org/core/author | "Park S.-Y."xsd:string |
| http://purl.uniprot.org/citations/19407142 | http://purl.uniprot.org/core/author | "Fujii H."xsd:string |
| http://purl.uniprot.org/citations/19407142 | http://purl.uniprot.org/core/author | "Fujii H."xsd:string |
| http://purl.uniprot.org/citations/19407142 | http://purl.uniprot.org/core/author | "Schroeder J.I."xsd:string |
| http://purl.uniprot.org/citations/19407142 | http://purl.uniprot.org/core/author | "Schroeder J.I."xsd:string |
| http://purl.uniprot.org/citations/19407142 | http://purl.uniprot.org/core/author | "Zhao Y."xsd:string |
| http://purl.uniprot.org/citations/19407142 | http://purl.uniprot.org/core/author | "Zhao Y."xsd:string |
| http://purl.uniprot.org/citations/19407142 | http://purl.uniprot.org/core/author | "Santiago J."xsd:string |
| http://purl.uniprot.org/citations/19407142 | http://purl.uniprot.org/core/author | "Santiago J."xsd:string |
| http://purl.uniprot.org/citations/19407142 | http://purl.uniprot.org/core/author | "McCourt P."xsd:string |
| http://purl.uniprot.org/citations/19407142 | http://purl.uniprot.org/core/author | "McCourt P."xsd:string |
| http://purl.uniprot.org/citations/19407142 | http://purl.uniprot.org/core/author | "Rodriguez P.L."xsd:string |
| http://purl.uniprot.org/citations/19407142 | http://purl.uniprot.org/core/author | "Rodriguez P.L."xsd:string |
| http://purl.uniprot.org/citations/19407142 | http://purl.uniprot.org/core/author | "Zhu J.-K."xsd:string |
| http://purl.uniprot.org/citations/19407142 | http://purl.uniprot.org/core/author | "Zhu J.-K."xsd:string |
| http://purl.uniprot.org/citations/19407142 | http://purl.uniprot.org/core/author | "Volkman B.F."xsd:string |
| http://purl.uniprot.org/citations/19407142 | http://purl.uniprot.org/core/author | "Volkman B.F."xsd:string |
| http://purl.uniprot.org/citations/19407142 | http://purl.uniprot.org/core/author | "Rodrigues A."xsd:string |
| http://purl.uniprot.org/citations/19407142 | http://purl.uniprot.org/core/author | "Rodrigues A."xsd:string |