| http://purl.uniprot.org/citations/19407814 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19407814 | http://www.w3.org/2000/01/rdf-schema#comment | "XBP-1, a transcription factor that drives the unfolded protein response (UPR), is activated in B cells when they differentiate to plasma cells. Here, we show that in the B cells, whose capacity to secrete IgM has been eliminated, XBP-1 is induced normally on induction of differentiation, suggesting that activation of XBP-1 in B cells is a differentiation-dependent event, but not the result of a UPR caused by the abundant synthesis of secreted IgM. Without XBP-1, B cells fail to signal effectively through the B-cell receptor. The signalling defects lead to aberrant expression of the plasma cell transcription factors IRF4 and Blimp-1, and altered levels of activation-induced cytidine deaminase and sphingosine-1-phosphate receptor. Using XBP-1-deficient/Blimp-1-GFP transgenic mice, we find that XBP-1-deficient B cells form antibody-secreting plasmablasts in response to initial immunization; however, these plasmablasts respond ineffectively to CXCL12. They fail to colonize the bone marrow and do not sustain antibody production. These findings define the role of XBP-1 in normal plasma cell development and have implications for management of B-cell malignancies."xsd:string |
| http://purl.uniprot.org/citations/19407814 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2009.117"xsd:string |
| http://purl.uniprot.org/citations/19407814 | http://purl.uniprot.org/core/author | "Ploegh H.L."xsd:string |
| http://purl.uniprot.org/citations/19407814 | http://purl.uniprot.org/core/author | "Hu C.C."xsd:string |
| http://purl.uniprot.org/citations/19407814 | http://purl.uniprot.org/core/author | "Dougan S.K."xsd:string |
| http://purl.uniprot.org/citations/19407814 | http://purl.uniprot.org/core/author | "McGehee A.M."xsd:string |
| http://purl.uniprot.org/citations/19407814 | http://purl.uniprot.org/core/author | "Love J.C."xsd:string |
| http://purl.uniprot.org/citations/19407814 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19407814 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/19407814 | http://purl.uniprot.org/core/pages | "1624-1636"xsd:string |
| http://purl.uniprot.org/citations/19407814 | http://purl.uniprot.org/core/title | "XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells."xsd:string |
| http://purl.uniprot.org/citations/19407814 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/19407814 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19407814 |
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