| http://purl.uniprot.org/citations/19409483 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19409483 | http://www.w3.org/2000/01/rdf-schema#comment | "Reactive oxygen species (ROS) have been suggested to regulate receptor activator of nuclear factor-kappaB ligand (RANKL)-stimulated osteoclast differentiation. Stimulation of wild-type mouse bone marrow monocyte/macrophage lineage (BMM) cells by RANKL down-regulated NADPH oxidase 2 (Nox2) mRNA expression by half. RANKL reciprocally increased Nox1 mRNA levels and newly induced Nox4 transcript expression. BMM cells from Nox1 knockout (Nox1(-/-)) as well as Nox2(-/-) mice generated ROS in response to RANKL and differentiated into osteoclasts in the same way as wild-type BMM cells, which was assessed by the appearance of tartrate-resistant acid phosphatase-positive, multinucleated cells having the ability to form resorption pits and by the expression of osteoclast marker genes. A small interfering RNA (siRNA) targeting Nox1 or Nox2 failed to inhibit the RANKL-stimulated ROS generation and osteoclast formation in wild-type cells, whereas Nox1 and Nox2 siRNAs significantly suppressed the ROS generation and osteoclast formation in Nox2(-/-) and Nox1(-/-) cells, respectively. We also confirmed that Nox4 siRNA did not affect the RANKL-dependent events in Nox2(-/-) cells, whereas p22(phox) siRNA suppressed the events in both wild-type and Nox1(-/-) cells. Collectively, our results suggest that there may be a flexible compensatory mechanism between Nox1 and Nox2 for RANKL-stimulated ROS generation to facilitate osteoclast differentiation."xsd:string |
| http://purl.uniprot.org/citations/19409483 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.freeradbiomed.2009.04.025"xsd:string |
| http://purl.uniprot.org/citations/19409483 | http://purl.uniprot.org/core/author | "Kawai T."xsd:string |
| http://purl.uniprot.org/citations/19409483 | http://purl.uniprot.org/core/author | "Yamamoto H."xsd:string |
| http://purl.uniprot.org/citations/19409483 | http://purl.uniprot.org/core/author | "Masuda K."xsd:string |
| http://purl.uniprot.org/citations/19409483 | http://purl.uniprot.org/core/author | "Sasaki H."xsd:string |
| http://purl.uniprot.org/citations/19409483 | http://purl.uniprot.org/core/author | "Matsuno K."xsd:string |
| http://purl.uniprot.org/citations/19409483 | http://purl.uniprot.org/core/author | "Yabe-Nishimura C."xsd:string |
| http://purl.uniprot.org/citations/19409483 | http://purl.uniprot.org/core/author | "Tominaga K."xsd:string |
| http://purl.uniprot.org/citations/19409483 | http://purl.uniprot.org/core/author | "Teshima-Kondo S."xsd:string |
| http://purl.uniprot.org/citations/19409483 | http://purl.uniprot.org/core/author | "Rokutan K."xsd:string |
| http://purl.uniprot.org/citations/19409483 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19409483 | http://purl.uniprot.org/core/name | "Free Radic Biol Med"xsd:string |
| http://purl.uniprot.org/citations/19409483 | http://purl.uniprot.org/core/pages | "189-199"xsd:string |
| http://purl.uniprot.org/citations/19409483 | http://purl.uniprot.org/core/title | "Receptor activator of nuclear factor-kappaB ligand-induced mouse osteoclast differentiation is associated with switching between NADPH oxidase homologues."xsd:string |
| http://purl.uniprot.org/citations/19409483 | http://purl.uniprot.org/core/volume | "47"xsd:string |
| http://purl.uniprot.org/citations/19409483 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19409483 |
| http://purl.uniprot.org/citations/19409483 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19409483 |
| http://purl.uniprot.org/uniprot/#_E0CYB0-mappedCitation-19409483 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19409483 |
| http://purl.uniprot.org/uniprot/#_E9Q7S3-mappedCitation-19409483 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19409483 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1X7-mappedCitation-19409483 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19409483 |
| http://purl.uniprot.org/uniprot/#_E9Q802-mappedCitation-19409483 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19409483 |
| http://purl.uniprot.org/uniprot/#_Q3U4P0-mappedCitation-19409483 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19409483 |
| http://purl.uniprot.org/uniprot/#_O35235-mappedCitation-19409483 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19409483 |