| http://purl.uniprot.org/citations/19409607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19409607 | http://www.w3.org/2000/01/rdf-schema#comment | "MicroRNAs (miRNAs) are posttranscriptional modulators of gene expression and play an important role in many developmental processes. We report here that expression of microRNA-145 (miR-145) is low in self-renewing human embryonic stem cells (hESCs) but highly upregulated during differentiation. We identify the pluripotency factors OCT4, SOX2, and KLF4 as direct targets of miR-145 and show that endogenous miR-145 represses the 3' untranslated regions of OCT4, SOX2, and KLF4. Increased miR-145 expression inhibits hESC self-renewal, represses expression of pluripotency genes, and induces lineage-restricted differentiation. Loss of miR-145 impairs differentiation and elevates OCT4, SOX2, and KLF4. Furthermore, we find that the miR-145 promoter is bound and repressed by OCT4 in hESCs. This work reveals a direct link between the core reprogramming factors and miR-145 and uncovers a double-negative feedback loop involving OCT4, SOX2, KLF4, and miR-145."xsd:string |
| http://purl.uniprot.org/citations/19409607 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2009.02.038"xsd:string |
| http://purl.uniprot.org/citations/19409607 | http://purl.uniprot.org/core/author | "Pan G."xsd:string |
| http://purl.uniprot.org/citations/19409607 | http://purl.uniprot.org/core/author | "Kosik K.S."xsd:string |
| http://purl.uniprot.org/citations/19409607 | http://purl.uniprot.org/core/author | "Thomson J.A."xsd:string |
| http://purl.uniprot.org/citations/19409607 | http://purl.uniprot.org/core/author | "Xu N."xsd:string |
| http://purl.uniprot.org/citations/19409607 | http://purl.uniprot.org/core/author | "Papagiannakopoulos T."xsd:string |
| http://purl.uniprot.org/citations/19409607 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19409607 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/19409607 | http://purl.uniprot.org/core/pages | "647-658"xsd:string |
| http://purl.uniprot.org/citations/19409607 | http://purl.uniprot.org/core/title | "MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells."xsd:string |
| http://purl.uniprot.org/citations/19409607 | http://purl.uniprot.org/core/volume | "137"xsd:string |
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