| http://purl.uniprot.org/citations/19410545 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19410545 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19410545 | http://www.w3.org/2000/01/rdf-schema#comment | "The histone H3 variant CenH3, called CENP-A in humans, is central in centromeric chromatin to ensure proper chromosome segregation. In the absence of an underlying DNA sequence, it is still unclear how CENP-A deposition at centromeres is determined. Here, we purified non-nucleosomal CENP-A complexes to identify direct CENP-A partners involved in such a mechanism and identified HJURP. HJURP was not detected in H3.1- or H3.3-containing complexes, indicating its specificity for CENP-A. HJURP centromeric localization is cell cycle regulated, and its transient appearance at the centromere coincides precisely with the proposed time window for new CENP-A deposition. Furthermore, HJURP downregulation leads to a major reduction in CENP-A at centromeres and impairs deposition of newly synthesized CENP-A, causing mitotic defects. We conclude that HJURP is a key factor for CENP-A deposition and maintenance at centromeres."xsd:string |
| http://purl.uniprot.org/citations/19410545 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2009.02.040"xsd:string |
| http://purl.uniprot.org/citations/19410545 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2009.02.040"xsd:string |
| http://purl.uniprot.org/citations/19410545 | http://purl.uniprot.org/core/author | "Nakamura Y."xsd:string |
| http://purl.uniprot.org/citations/19410545 | http://purl.uniprot.org/core/author | "Nakamura Y."xsd:string |
| http://purl.uniprot.org/citations/19410545 | http://purl.uniprot.org/core/author | "Tagami H."xsd:string |
| http://purl.uniprot.org/citations/19410545 | http://purl.uniprot.org/core/author | "Tagami H."xsd:string |
| http://purl.uniprot.org/citations/19410545 | http://purl.uniprot.org/core/author | "Roche D."xsd:string |
| http://purl.uniprot.org/citations/19410545 | http://purl.uniprot.org/core/author | "Roche D."xsd:string |
| http://purl.uniprot.org/citations/19410545 | http://purl.uniprot.org/core/author | "Nakatani Y."xsd:string |
| http://purl.uniprot.org/citations/19410545 | http://purl.uniprot.org/core/author | "Nakatani Y."xsd:string |
| http://purl.uniprot.org/citations/19410545 | http://purl.uniprot.org/core/author | "Daigo Y."xsd:string |
| http://purl.uniprot.org/citations/19410545 | http://purl.uniprot.org/core/author | "Daigo Y."xsd:string |
| http://purl.uniprot.org/citations/19410545 | http://purl.uniprot.org/core/author | "Ray-Gallet D."xsd:string |
| http://purl.uniprot.org/citations/19410545 | http://purl.uniprot.org/core/author | "Ray-Gallet D."xsd:string |
| http://purl.uniprot.org/citations/19410545 | http://purl.uniprot.org/core/author | "Lacoste N."xsd:string |
| http://purl.uniprot.org/citations/19410545 | http://purl.uniprot.org/core/author | "Lacoste N."xsd:string |
| http://purl.uniprot.org/citations/19410545 | http://purl.uniprot.org/core/author | "Almouzni-Pettinotti G."xsd:string |
| http://purl.uniprot.org/citations/19410545 | http://purl.uniprot.org/core/author | "Almouzni-Pettinotti G."xsd:string |
| http://purl.uniprot.org/citations/19410545 | http://purl.uniprot.org/core/author | "Dunleavy E.M."xsd:string |
| http://purl.uniprot.org/citations/19410545 | http://purl.uniprot.org/core/author | "Dunleavy E.M."xsd:string |
| http://purl.uniprot.org/citations/19410545 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19410545 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |