| http://purl.uniprot.org/citations/19410617 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19410617 | http://www.w3.org/2000/01/rdf-schema#comment | "Type 1 diabetes (T1D) is a T-cell-mediated autoimmune disease. Although the precise mechanisms leading to the destruction of islet beta cells are unknown, diverse studies support a role of the CXCR3-binding chemokines. A combination of a case (n = 447)-control (n = 300) and family (n = 221) analysis was performed to investigate the role of the CXCL9 (rs10336, rs3733236) and CXCL10 (rs3921, rs35795399 and rs8878) polymorphisms and their interaction with HLA high-risk haplotypes DQ2(DQA*0501-DQB*0201)-DQ8(DQA*0301-DQB*0302) in T1D. In addition, the mRNA expression of these genes and of the CXCR3 in peripheral blood mononuclear cells (PBMCs) of T1D patients was studied. In the family analysis, an overtransmission of the allele T and G of the polymorphisms rs35795399 and rs8878 in the whole group (p = 0.0520 and p = 0.0290, respectively) as well as in combination with the HLA-high risk haplotypes (p = 0.0209 and 0.0340, respectively) were observed. In addition, the haplotype rs8878G-rs35795399T was more often transmitted from parents to affected offspring, whereas the haplotype rs8878A-rs35795399C was less often transmitted (p = 0.0130 and p = 0.0201, respectively). Nevertheless these associations did not remain significant after correction for multiple testing, and they could not be corroborated in the case-control analysis. Although we did not find an association of the CXCL9 and CXCL10 polymorphisms with type 1 diabetes in the German population, we cannot discard their role in other populations or other autoimmune diseases."xsd:string |
| http://purl.uniprot.org/citations/19410617 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.humimm.2009.04.031"xsd:string |
| http://purl.uniprot.org/citations/19410617 | http://purl.uniprot.org/core/author | "Badenhoop K."xsd:string |
| http://purl.uniprot.org/citations/19410617 | http://purl.uniprot.org/core/author | "Seidl C."xsd:string |
| http://purl.uniprot.org/citations/19410617 | http://purl.uniprot.org/core/author | "Bohme A."xsd:string |
| http://purl.uniprot.org/citations/19410617 | http://purl.uniprot.org/core/author | "Bruck P."xsd:string |
| http://purl.uniprot.org/citations/19410617 | http://purl.uniprot.org/core/author | "Kahles H."xsd:string |
| http://purl.uniprot.org/citations/19410617 | http://purl.uniprot.org/core/author | "Ramos-Lopez E."xsd:string |
| http://purl.uniprot.org/citations/19410617 | http://purl.uniprot.org/core/author | "Bartsch W."xsd:string |
| http://purl.uniprot.org/citations/19410617 | http://purl.uniprot.org/core/author | "Penna-Martinez M."xsd:string |
| http://purl.uniprot.org/citations/19410617 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19410617 | http://purl.uniprot.org/core/name | "Hum Immunol"xsd:string |
| http://purl.uniprot.org/citations/19410617 | http://purl.uniprot.org/core/pages | "552-555"xsd:string |
| http://purl.uniprot.org/citations/19410617 | http://purl.uniprot.org/core/title | "Polymorphisms of CXCR3-binding chemokines in type 1 diabetes."xsd:string |
| http://purl.uniprot.org/citations/19410617 | http://purl.uniprot.org/core/volume | "70"xsd:string |
| http://purl.uniprot.org/citations/19410617 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19410617 |
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