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http://purl.uniprot.org/citations/19411392http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19411392http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To determine the prevalence of anti-cyclic citrullinated peptide (anti-CCP) antibodies in unaffected relatives of North American Native probands with rheumatoid arthritis (RA); and the associations of the shared epitope (SE) and HLA-DRB1*0901 with RA and anti-CCP antibodies.

Methods

The subjects were RA probands, affected relatives, unaffected first-degree (FDR) and more distant relatives, and unaffected controls from the same population. HLA-DRB1 typing was determined by DNA sequencing and anti-CCP antibodies were determined by ELISA.

Results

DRB1*0901, SE, and SE/DRB1*0901 genotypes were all associated with RA. SE/DRB1*0901, but not other SE genotypes, was associated with disease onset at age<16 years. The frequency of anti-CCP antibodies was 82% in RA probands, 17% in FDR, 11% in more distant relatives, and 3% in controls. Among unaffected relatives, a significant increased risk of anti-CCP was associated with SE/DRB1*0901 genotype, but not with SE.

Conclusion

An independent association of the non-SE allele DRB1*0901 with RA was confirmed in this population, and this allele in combination with a SE allele was associated with younger age at disease onset. FDR of RA probands have a higher prevalence of anti-CCP antibodies than more distant relatives and unrelated controls, suggesting a gradient of risk for disease development. Immunogenetic risks may act early in disease pathogenesis at the level of initiation of RA autoantibody formation; however, it is not clear what additional genetic and environmental risks are involved in progression to clinical disease."xsd:string
http://purl.uniprot.org/citations/19411392http://purl.org/dc/terms/identifier"doi:10.3899/jrheum.080855"xsd:string
http://purl.uniprot.org/citations/19411392http://purl.uniprot.org/core/author"Elias B."xsd:string
http://purl.uniprot.org/citations/19411392http://purl.uniprot.org/core/author"Schroeder M."xsd:string
http://purl.uniprot.org/citations/19411392http://purl.uniprot.org/core/author"Fritzler M.J."xsd:string
http://purl.uniprot.org/citations/19411392http://purl.uniprot.org/core/author"Hart D."xsd:string
http://purl.uniprot.org/citations/19411392http://purl.uniprot.org/core/author"Robinson D.B."xsd:string
http://purl.uniprot.org/citations/19411392http://purl.uniprot.org/core/author"Smolik I."xsd:string
http://purl.uniprot.org/citations/19411392http://purl.uniprot.org/core/author"Cheang M."xsd:string
http://purl.uniprot.org/citations/19411392http://purl.uniprot.org/core/author"Oen K."xsd:string
http://purl.uniprot.org/citations/19411392http://purl.uniprot.org/core/author"El-Gabalawy H.S."xsd:string
http://purl.uniprot.org/citations/19411392http://purl.uniprot.org/core/author"Markland J."xsd:string
http://purl.uniprot.org/citations/19411392http://purl.uniprot.org/core/author"Montes-Aldana G."xsd:string
http://purl.uniprot.org/citations/19411392http://purl.uniprot.org/core/author"Peschken C.A."xsd:string
http://purl.uniprot.org/citations/19411392http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19411392http://purl.uniprot.org/core/name"J Rheumatol"xsd:string
http://purl.uniprot.org/citations/19411392http://purl.uniprot.org/core/pages"1130-1135"xsd:string
http://purl.uniprot.org/citations/19411392http://purl.uniprot.org/core/title"Immunogenetic risks of anti-cyclical citrullinated peptide antibodies in a North American Native population with rheumatoid arthritis and their first-degree relatives."xsd:string
http://purl.uniprot.org/citations/19411392http://purl.uniprot.org/core/volume"36"xsd:string
http://purl.uniprot.org/citations/19411392http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19411392
http://purl.uniprot.org/citations/19411392http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19411392
http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-19411392http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19411392
http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-19411392http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19411392
http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-19411392http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19411392
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