| http://purl.uniprot.org/citations/19412173 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19412173 | http://www.w3.org/2000/01/rdf-schema#comment | "In salt-sensitive hypertension, the accumulation of Na(+) in tissue has been presumed to be accompanied by a commensurate retention of water to maintain the isotonicity of body fluids. We show here that a high-salt diet (HSD) in rats leads to interstitial hypertonic Na(+) accumulation in skin, resulting in increased density and hyperplasia of the lymphcapillary network. The mechanisms underlying these effects on lymphatics involve activation of tonicity-responsive enhancer binding protein (TonEBP) in mononuclear phagocyte system (MPS) cells infiltrating the interstitium of the skin. TonEBP binds the promoter of the gene encoding vascular endothelial growth factor-C (VEGF-C, encoded by Vegfc) and causes VEGF-C secretion by macrophages. MPS cell depletion or VEGF-C trapping by soluble VEGF receptor-3 blocks VEGF-C signaling, augments interstitial hypertonic volume retention, decreases endothelial nitric oxide synthase expression and elevates blood pressure in response to HSD. Our data show that TonEBP-VEGF-C signaling in MPS cells is a major determinant of extracellular volume and blood pressure homeostasis and identify VEGFC as an osmosensitive, hypertonicity-driven gene intimately involved in salt-induced hypertension."xsd:string |
| http://purl.uniprot.org/citations/19412173 | http://purl.org/dc/terms/identifier | "doi:10.1038/nm.1960"xsd:string |
| http://purl.uniprot.org/citations/19412173 | http://purl.uniprot.org/core/author | "Kerjaschki D."xsd:string |
| http://purl.uniprot.org/citations/19412173 | http://purl.uniprot.org/core/author | "Hilgers K.F."xsd:string |
| http://purl.uniprot.org/citations/19412173 | http://purl.uniprot.org/core/author | "Alitalo K."xsd:string |
| http://purl.uniprot.org/citations/19412173 | http://purl.uniprot.org/core/author | "Luft F.C."xsd:string |
| http://purl.uniprot.org/citations/19412173 | http://purl.uniprot.org/core/author | "Tammela T."xsd:string |
| http://purl.uniprot.org/citations/19412173 | http://purl.uniprot.org/core/author | "Park J.K."xsd:string |
| http://purl.uniprot.org/citations/19412173 | http://purl.uniprot.org/core/author | "Kurtz A."xsd:string |
| http://purl.uniprot.org/citations/19412173 | http://purl.uniprot.org/core/author | "Wagner H."xsd:string |
| http://purl.uniprot.org/citations/19412173 | http://purl.uniprot.org/core/author | "Muller D.N."xsd:string |
| http://purl.uniprot.org/citations/19412173 | http://purl.uniprot.org/core/author | "Machnik A."xsd:string |
| http://purl.uniprot.org/citations/19412173 | http://purl.uniprot.org/core/author | "Eckardt K.U."xsd:string |
| http://purl.uniprot.org/citations/19412173 | http://purl.uniprot.org/core/author | "van Rooijen N."xsd:string |
| http://purl.uniprot.org/citations/19412173 | http://purl.uniprot.org/core/author | "Beck F.X."xsd:string |
| http://purl.uniprot.org/citations/19412173 | http://purl.uniprot.org/core/author | "Jantsch J."xsd:string |
| http://purl.uniprot.org/citations/19412173 | http://purl.uniprot.org/core/author | "Neuhofer W."xsd:string |
| http://purl.uniprot.org/citations/19412173 | http://purl.uniprot.org/core/author | "Goss J."xsd:string |
| http://purl.uniprot.org/citations/19412173 | http://purl.uniprot.org/core/author | "Dahlmann A."xsd:string |
| http://purl.uniprot.org/citations/19412173 | http://purl.uniprot.org/core/author | "Dietsch P."xsd:string |
| http://purl.uniprot.org/citations/19412173 | http://purl.uniprot.org/core/author | "Titze J."xsd:string |
| http://purl.uniprot.org/citations/19412173 | http://purl.uniprot.org/core/author | "Ziomber A."xsd:string |
| http://purl.uniprot.org/citations/19412173 | http://purl.uniprot.org/core/author | "Derer W."xsd:string |
| http://purl.uniprot.org/citations/19412173 | http://purl.uniprot.org/core/author | "Machura K."xsd:string |