| http://purl.uniprot.org/citations/19414772 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19414772 | http://www.w3.org/2000/01/rdf-schema#comment | "Hematopoietic progenitor kinase 1 (HPK1) is a hematopoietic cell-restricted member of the Ste20 kinases that acts as a negative regulator of T cell functions through the AP-1, NFAT, and NFkappaB pathways. Using HPK1-deficient (HPK1(-/-)) mice, we report in this study a novel role for HPK1 in dendritic cells (DCs). Specifically, we observed that matured HPK1(-/-) bone marrow-derived DCs (BMDCs) are superior to their wild-type (WT) counterpart in stimulating T cell proliferation in vivo and in vitro. Several characteristics of HPK1(-/-) BMDCs may account for this enhanced activity: Matured HPK1(-/-) BMDCs express higher levels of costimulatory molecules CD80, CD86, and I-A(b) as well as produce more proinflammatory cytokines IL-12, IL-1beta, TNF-alpha, and IL-6 than their WT littermates. The role of HPK1 as a proapoptotic molecule was assessed post activation with LPS, and results indicated that HPK1(-/-) BMDCs are significantly resistant to LPS-induced apoptosis. Our results led us to investigate the role of HPK1(-/-) BMDCs in tumor immunotherapy. Using a s.c. murine model of Lewis Lung Carcinoma, we found that HPK1(-/-) BMDCs eliminate established s.c. Lewis Lung Carcinoma more efficiently than their WT counterpart. Our data reveal a novel role for HPK1 as a negative regulator of DC functions, identifying its potential as a molecular target for DC-based immunotherapy against cancers."xsd:string |
| http://purl.uniprot.org/citations/19414772 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.0802631"xsd:string |
| http://purl.uniprot.org/citations/19414772 | http://purl.uniprot.org/core/author | "Kiefer F."xsd:string |
| http://purl.uniprot.org/citations/19414772 | http://purl.uniprot.org/core/author | "Sawasdikosol S."xsd:string |
| http://purl.uniprot.org/citations/19414772 | http://purl.uniprot.org/core/author | "Bhardwaj N."xsd:string |
| http://purl.uniprot.org/citations/19414772 | http://purl.uniprot.org/core/author | "Alzabin S."xsd:string |
| http://purl.uniprot.org/citations/19414772 | http://purl.uniprot.org/core/author | "Burakoff S."xsd:string |
| http://purl.uniprot.org/citations/19414772 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19414772 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/19414772 | http://purl.uniprot.org/core/pages | "6187-6194"xsd:string |
| http://purl.uniprot.org/citations/19414772 | http://purl.uniprot.org/core/title | "Hematopoietic progenitor kinase 1 is a negative regulator of dendritic cell activation."xsd:string |
| http://purl.uniprot.org/citations/19414772 | http://purl.uniprot.org/core/volume | "182"xsd:string |
| http://purl.uniprot.org/citations/19414772 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19414772 |
| http://purl.uniprot.org/citations/19414772 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19414772 |
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