| http://purl.uniprot.org/citations/19414791 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19414791 | http://www.w3.org/2000/01/rdf-schema#comment | "The intracellular parasite Toxoplasma gondii can establish persistent infection in the brain of a mammalian host, a standoff that involves the active participation of host CD8 T cells to control infection. CD8 T cells generally protect against intracellular pathogens by local delivery of effector molecules upon recognition of specific pathogen Ags on invaded host cells. However, the interactions between CD8 T cells, T. gondii, and APCs in the brain have not yet been examined. In this study we have used a mouse infection model in conjunction with two-photon microscopy of living brain tissue and confocal microscopy of fixed brain sections to examine the interactions between CD8 T cells, parasites, and APCs from chronically infected mice. We found that Ag-specific CD8 T cells were recruited to the brains of infected mice and persisted there in the presence of ongoing Ag recognition. Cerebral CD8 T cells made transient contacts with granuloma-like structures containing parasites and with individual CD11b(+) APCs, including some that did not contain parasites. In contrast, T cells ignored intact Ag-bearing cysts and did not contact astrocytes or neurons, including neurons containing parasites or cysts. Our data represent the first direct observation of the dynamics of T cell-parasite interactions within living tissue and provide a new perspective for understanding immune responses to persistent pathogens in the brain."xsd:string |
| http://purl.uniprot.org/citations/19414791 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.0804307"xsd:string |
| http://purl.uniprot.org/citations/19414791 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/19414791 | http://purl.uniprot.org/core/author | "Striepen B."xsd:string |
| http://purl.uniprot.org/citations/19414791 | http://purl.uniprot.org/core/author | "van Dooren G.G."xsd:string |
| http://purl.uniprot.org/citations/19414791 | http://purl.uniprot.org/core/author | "Schaeffer M."xsd:string |
| http://purl.uniprot.org/citations/19414791 | http://purl.uniprot.org/core/author | "Han S.J."xsd:string |
| http://purl.uniprot.org/citations/19414791 | http://purl.uniprot.org/core/author | "Herzmark P."xsd:string |
| http://purl.uniprot.org/citations/19414791 | http://purl.uniprot.org/core/author | "Robey E.A."xsd:string |
| http://purl.uniprot.org/citations/19414791 | http://purl.uniprot.org/core/author | "Chtanova T."xsd:string |
| http://purl.uniprot.org/citations/19414791 | http://purl.uniprot.org/core/author | "Roysam B."xsd:string |
| http://purl.uniprot.org/citations/19414791 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19414791 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/19414791 | http://purl.uniprot.org/core/pages | "6379-6393"xsd:string |
| http://purl.uniprot.org/citations/19414791 | http://purl.uniprot.org/core/title | "Dynamic imaging of T cell-parasite interactions in the brains of mice chronically infected with Toxoplasma gondii."xsd:string |
| http://purl.uniprot.org/citations/19414791 | http://purl.uniprot.org/core/volume | "182"xsd:string |
| http://purl.uniprot.org/citations/19414791 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19414791 |
| http://purl.uniprot.org/citations/19414791 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19414791 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGP1-mappedCitation-19414791 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19414791 |
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| http://purl.uniprot.org/uniprot/#_P70443-mappedCitation-19414791 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19414791 |
| http://purl.uniprot.org/uniprot/#_P40240-mappedCitation-19414791 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19414791 |
| http://purl.uniprot.org/uniprot/#_P06332-mappedCitation-19414791 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19414791 |