| http://purl.uniprot.org/citations/19414799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19414799 | http://www.w3.org/2000/01/rdf-schema#comment | "Thymic stromal lymphopoietin was recently identified as a master switch for the development of allergen-driven Th2 responses. However, the role of thymic stromal lymphopoietin (TSLP) in the development of helminth-induced Th2 responses is unclear. Here, using TSLPR(-/-) mice, we show that while TSLPR signaling participates in the development of Schistosoma mansoni egg-induced CD4(+) Th2 responses, it plays only a transient role in the development of Th2-dependent pathology in the lung, liver, and intestine. Studies conducted in a pulmonary granuloma model showed that while a reduction in IL-4/IL-13-dependent granulomatous inflammation and tissue eosinophilia was observed in TSLPR(-/-) mice undergoing a primary response, lesion formation was not affected during a secondary granulomatous response, even though IL-5 and IL-13 were modestly reduced in the knockout mice. To evaluate the importance of TSLPR signaling in the development of a chronic Th2-dependent response, TSLPR(-/-) mice were also infected with S. mansoni cercariae. Here, the only significant difference noted in TSLPR(-/-) mice was a modest decrease in liver fibrosis in acutely infected animals. The transient decrease in fibrosis was associated with increased production of the antifibrotic cytokine IFN-gamma and decreased production of the profibrotic cytokine IL-13. Although the altered cytokine response persisted in chronically infected TSLPR(-/-) mice, it failed to reduce granuloma formation or fibrosis, confirming that TSLPR signaling plays a limited role in the development of chronic Th2-dependent pathology. Collectively, these findings suggest that while TSLPR signaling serves a key role in allergen-driven Th2 responses, it exerts minor regulatory activity during this chronic helminth infection."xsd:string |
| http://purl.uniprot.org/citations/19414799 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.0900181"xsd:string |
| http://purl.uniprot.org/citations/19414799 | http://purl.uniprot.org/core/author | "Comeau M.R."xsd:string |
| http://purl.uniprot.org/citations/19414799 | http://purl.uniprot.org/core/author | "Cheever A.W."xsd:string |
| http://purl.uniprot.org/citations/19414799 | http://purl.uniprot.org/core/author | "Mentink-Kane M.M."xsd:string |
| http://purl.uniprot.org/citations/19414799 | http://purl.uniprot.org/core/author | "Pesce J.T."xsd:string |
| http://purl.uniprot.org/citations/19414799 | http://purl.uniprot.org/core/author | "Ramalingam T.R."xsd:string |
| http://purl.uniprot.org/citations/19414799 | http://purl.uniprot.org/core/author | "Wynn T.A."xsd:string |
| http://purl.uniprot.org/citations/19414799 | http://purl.uniprot.org/core/author | "Ziegler S.F."xsd:string |
| http://purl.uniprot.org/citations/19414799 | http://purl.uniprot.org/core/author | "Madala S."xsd:string |
| http://purl.uniprot.org/citations/19414799 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19414799 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/19414799 | http://purl.uniprot.org/core/pages | "6452-6459"xsd:string |
| http://purl.uniprot.org/citations/19414799 | http://purl.uniprot.org/core/title | "Regulation of helminth-induced Th2 responses by thymic stromal lymphopoietin."xsd:string |
| http://purl.uniprot.org/citations/19414799 | http://purl.uniprot.org/core/volume | "182"xsd:string |
| http://purl.uniprot.org/citations/19414799 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19414799 |
| http://purl.uniprot.org/citations/19414799 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19414799 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGP1-mappedCitation-19414799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19414799 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0F5-mappedCitation-19414799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19414799 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JF13-mappedCitation-19414799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19414799 |
| http://purl.uniprot.org/uniprot/#_Q05DC7-mappedCitation-19414799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19414799 |
| http://purl.uniprot.org/uniprot/#_Q3TCZ1-mappedCitation-19414799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19414799 |
| http://purl.uniprot.org/uniprot/#_Q8CII9-mappedCitation-19414799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19414799 |
| http://purl.uniprot.org/uniprot/#_Q9JIE6-mappedCitation-19414799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19414799 |