| http://purl.uniprot.org/citations/19416713 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19416713 | http://www.w3.org/2000/01/rdf-schema#comment | "We have previously shown that expression of the transcription factor ARNT/HIF1beta is reduced in islets of humans with type 2 diabetes. We have now found that ARNT is also reduced in livers of diabetics. To study the functional effect of its reduction, we created mice with liver-specific ablation (L-ARNT KO) using ARNT loxP mice and adenoviral-mediated delivery of Cre. L-ARNT KO mice had normal blood glucose but increased fed insulin levels. These mice also exhibited features of type 2 diabetes with increased hepatic gluconeogenesis, increased lipogenic gene expression, and low serum beta-hydroxybutyrate. These effects appear to be secondary to increased expression of CCAAT/enhancer-binding protein alpha (C/EBPalpha), farnesoid X receptor (FXR), and sterol response element-binding protein 1c (SREBP-1c) and a reduction in phosphorylation of AMPK without changes in the expression of enzymes in ketogenesis, fatty acid oxidation, or FGF21. These results demonstrate that a deficiency of ARNT action in the liver, coupled with that in beta cells, could contribute to the metabolic phenotype of human type 2 diabetes."xsd:string |
| http://purl.uniprot.org/citations/19416713 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cmet.2009.04.001"xsd:string |
| http://purl.uniprot.org/citations/19416713 | http://purl.uniprot.org/core/author | "Kahn C.R."xsd:string |
| http://purl.uniprot.org/citations/19416713 | http://purl.uniprot.org/core/author | "Lee K."xsd:string |
| http://purl.uniprot.org/citations/19416713 | http://purl.uniprot.org/core/author | "Suzuki R."xsd:string |
| http://purl.uniprot.org/citations/19416713 | http://purl.uniprot.org/core/author | "Gonzalez F.J."xsd:string |
| http://purl.uniprot.org/citations/19416713 | http://purl.uniprot.org/core/author | "Tran T."xsd:string |
| http://purl.uniprot.org/citations/19416713 | http://purl.uniprot.org/core/author | "Saha A.K."xsd:string |
| http://purl.uniprot.org/citations/19416713 | http://purl.uniprot.org/core/author | "Wang X.L."xsd:string |
| http://purl.uniprot.org/citations/19416713 | http://purl.uniprot.org/core/author | "Goldfine A."xsd:string |
| http://purl.uniprot.org/citations/19416713 | http://purl.uniprot.org/core/author | "Ruderman N.B."xsd:string |
| http://purl.uniprot.org/citations/19416713 | http://purl.uniprot.org/core/author | "Gunton J.E."xsd:string |
| http://purl.uniprot.org/citations/19416713 | http://purl.uniprot.org/core/author | "Patti M.E."xsd:string |
| http://purl.uniprot.org/citations/19416713 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19416713 | http://purl.uniprot.org/core/name | "Cell Metab"xsd:string |
| http://purl.uniprot.org/citations/19416713 | http://purl.uniprot.org/core/pages | "428-439"xsd:string |
| http://purl.uniprot.org/citations/19416713 | http://purl.uniprot.org/core/title | "Ablation of ARNT/HIF1beta in liver alters gluconeogenesis, lipogenic gene expression, and serum ketones."xsd:string |
| http://purl.uniprot.org/citations/19416713 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/19416713 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19416713 |
| http://purl.uniprot.org/citations/19416713 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19416713 |
| http://purl.uniprot.org/uniprot/#_A0A0G2YDK5-mappedCitation-19416713 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19416713 |
| http://purl.uniprot.org/uniprot/#_A0A0G2YJ29-mappedCitation-19416713 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19416713 |
| http://purl.uniprot.org/uniprot/#_F7C9F6-mappedCitation-19416713 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19416713 |
| http://purl.uniprot.org/uniprot/#_E9QLT6-mappedCitation-19416713 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19416713 |