| http://purl.uniprot.org/citations/19416714 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19416714 | http://www.w3.org/2000/01/rdf-schema#comment | "The endoplasmic reticulum (ER) is an organelle associated with lipid metabolism. However, the involvement of the ER in nutritional status-dependent energy homeostasis is largely unknown. We demonstrate that IRE-1, an ER protein known to be involved in the unfolded protein response, and HSP-4, an ER chaperone, regulate expression of the novel fasting-induced lipases FIL-1 and FIL-2, which induce fat granule hydrolysis upon fasting in C. elegans. RNAi and ectopic expression experiments demonstrated that FIL-1 and FIL-2 are both necessary and sufficient for fasting-induced fat granule breakdown. Failure of ire-1 and hsp-4 mutant animals to hydrolyze fat granules during starvation impaired their motility, which was rescued by glucose supplementation, implicating the importance of ire-1/hsp-4-dependent lipolysis for energy supply from stored fat during fasting. These data suggest that the ER-resident proteins IRE-1 and HSP-4 are key nutritional sensors that modulate expression of inducible lipases to maintain whole-body energy homeostasis in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/19416714 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cmet.2009.04.004"xsd:string |
| http://purl.uniprot.org/citations/19416714 | http://purl.uniprot.org/core/author | "Lee J.H."xsd:string |
| http://purl.uniprot.org/citations/19416714 | http://purl.uniprot.org/core/author | "Lee J."xsd:string |
| http://purl.uniprot.org/citations/19416714 | http://purl.uniprot.org/core/author | "Jo H."xsd:string |
| http://purl.uniprot.org/citations/19416714 | http://purl.uniprot.org/core/author | "Shim J."xsd:string |
| http://purl.uniprot.org/citations/19416714 | http://purl.uniprot.org/core/author | "Kim J.B."xsd:string |
| http://purl.uniprot.org/citations/19416714 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19416714 | http://purl.uniprot.org/core/name | "Cell Metab"xsd:string |
| http://purl.uniprot.org/citations/19416714 | http://purl.uniprot.org/core/pages | "440-448"xsd:string |
| http://purl.uniprot.org/citations/19416714 | http://purl.uniprot.org/core/title | "IRE-1 and HSP-4 contribute to energy homeostasis via fasting-induced lipases in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/19416714 | http://purl.uniprot.org/core/volume | "9"xsd:string |
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