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http://purl.uniprot.org/citations/19419966http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19419966http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19419966http://www.w3.org/2000/01/rdf-schema#comment"Antiviral immune responses are initiated through Toll-like receptors (TLRs) and RIG-I (retinoic acid-inducible gene-I)-like RNA helicases that recognize nucleic acids from distinct viruses. In this study, we show that the tyrosine kinase c-Src participates in antiviral responses induced by the cytoplasmic RNA helicase RIG-I. Sendai virus (SV), which is recognized by RIG-I, induced c-Src phosphorylation. Functional impairment of c-Src through chemical inhibition or transient expression of a c-Src kinase-inactive mutant attenuated production of endogenous antiviral proteins after SV infection or after expression of RIG-I or its adapter protein MAVS. Importantly, SV-stimulated synthesis of antiviral proteins was significantly impaired in cells treated with c-Src small interfering RNA and in cells from c-Src-deficient mice. In addition, we found that c-Src interacted with components of the RIG-I pathway: RIG-I, MAVS, and TRAF3 (tumor necrosis factor receptor-associated factor-3). The interaction between c-Src and TRAF3 was found to occur within the RING domain of TRAF3. Taken together, our results suggest that c-Src enhances RIG-I-mediated signaling, acting at the level of TRAF3."xsd:string
http://purl.uniprot.org/citations/19419966http://purl.org/dc/terms/identifier"doi:10.1074/jbc.m808233200"xsd:string
http://purl.uniprot.org/citations/19419966http://purl.org/dc/terms/identifier"doi:10.1074/jbc.m808233200"xsd:string
http://purl.uniprot.org/citations/19419966http://purl.uniprot.org/core/author"Nguyen T.T."xsd:string
http://purl.uniprot.org/citations/19419966http://purl.uniprot.org/core/author"Nguyen T.T."xsd:string
http://purl.uniprot.org/citations/19419966http://purl.uniprot.org/core/author"Fitzgerald K.A."xsd:string
http://purl.uniprot.org/citations/19419966http://purl.uniprot.org/core/author"Fitzgerald K.A."xsd:string
http://purl.uniprot.org/citations/19419966http://purl.uniprot.org/core/author"Anthonsen M.W."xsd:string
http://purl.uniprot.org/citations/19419966http://purl.uniprot.org/core/author"Anthonsen M.W."xsd:string
http://purl.uniprot.org/citations/19419966http://purl.uniprot.org/core/author"Johnsen I.B."xsd:string
http://purl.uniprot.org/citations/19419966http://purl.uniprot.org/core/author"Johnsen I.B."xsd:string
http://purl.uniprot.org/citations/19419966http://purl.uniprot.org/core/author"Bergstroem B."xsd:string
http://purl.uniprot.org/citations/19419966http://purl.uniprot.org/core/author"Bergstroem B."xsd:string
http://purl.uniprot.org/citations/19419966http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19419966http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19419966http://purl.uniprot.org/core/name"J. Biol. Chem."xsd:string
http://purl.uniprot.org/citations/19419966http://purl.uniprot.org/core/name"J. Biol. Chem."xsd:string
http://purl.uniprot.org/citations/19419966http://purl.uniprot.org/core/pages"19122-19131"xsd:string
http://purl.uniprot.org/citations/19419966http://purl.uniprot.org/core/pages"19122-19131"xsd:string
http://purl.uniprot.org/citations/19419966http://purl.uniprot.org/core/title"The tyrosine kinase c-Src enhances RIG-I (retinoic acid-inducible gene I)-elicited antiviral signaling."xsd:string
http://purl.uniprot.org/citations/19419966http://purl.uniprot.org/core/title"The tyrosine kinase c-Src enhances RIG-I (retinoic acid-inducible gene I)-elicited antiviral signaling."xsd:string
http://purl.uniprot.org/citations/19419966http://purl.uniprot.org/core/volume"284"xsd:string
http://purl.uniprot.org/citations/19419966http://purl.uniprot.org/core/volume"284"xsd:string
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