| http://purl.uniprot.org/citations/19420356 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19420356 | http://www.w3.org/2000/01/rdf-schema#comment | "Pathologische Anatomie Leiden-endothelium antibody has been used for more than 20 years as a marker for vascular endothelium. Despite its widespread use, the target of this antibody was only recently identified as plasmalemma vesicle-associated protein-1 (PV-1). However, no function has been identified for this molecule. Here we report that activation of human umbilical vein endothelial cells with tumor necrosis factor-alpha resulted in a remarkable redistribution of PV-1 toward the peripheral areas of the cells. Furthermore, in vitro endpoint transmigration experiments showed that transcellularly migrating lymphocytes are surrounded by rings containing PV-1 and caveolin-1. Moreover, PV-1 associates physically with vimentin. In addition, administration of anti-PV-1 antibody during capillary flow assays resulted in a significant inhibition of lymphocyte transmigration through the endothelial cell layer, whereas rolling and adhesion were unaffected. In vivo blockage of PV-1 by an antibody in acute peritonitis and air pouch model resulted in a significant decrease in the number of migrating leukocytes. Here we thus define leukocyte transendothelial migration as the first known function for PV-1."xsd:string |
| http://purl.uniprot.org/citations/19420356 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2008-11-188763"xsd:string |
| http://purl.uniprot.org/citations/19420356 | http://purl.uniprot.org/core/author | "Jalkanen S."xsd:string |
| http://purl.uniprot.org/citations/19420356 | http://purl.uniprot.org/core/author | "Salmi M."xsd:string |
| http://purl.uniprot.org/citations/19420356 | http://purl.uniprot.org/core/author | "Henttinen T."xsd:string |
| http://purl.uniprot.org/citations/19420356 | http://purl.uniprot.org/core/author | "Karikoski M."xsd:string |
| http://purl.uniprot.org/citations/19420356 | http://purl.uniprot.org/core/author | "Auvinen K."xsd:string |
| http://purl.uniprot.org/citations/19420356 | http://purl.uniprot.org/core/author | "Keuschnigg J."xsd:string |
| http://purl.uniprot.org/citations/19420356 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19420356 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/19420356 | http://purl.uniprot.org/core/pages | "478-484"xsd:string |
| http://purl.uniprot.org/citations/19420356 | http://purl.uniprot.org/core/title | "The prototype endothelial marker PAL-E is a leukocyte trafficking molecule."xsd:string |
| http://purl.uniprot.org/citations/19420356 | http://purl.uniprot.org/core/volume | "114"xsd:string |
| http://purl.uniprot.org/citations/19420356 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19420356 |
| http://purl.uniprot.org/citations/19420356 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19420356 |
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