| http://purl.uniprot.org/citations/19422799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19422799 | http://www.w3.org/2000/01/rdf-schema#comment | "The transcription factor ATF-2, a member of the ATF/CREB family, is a target of p38 that are involved in stress-induced apoptosis and in Toll-like receptor (TLR)-mediated signaling. Phosphorylation of ATF-2 at Thr-71 was enhanced by treating of RAW264.7 macrophage cells with either LPS, MALP-2, or CpG-ODN. LPS treatment enhanced the trans-activation capacity of ATF-2. Among multiple LPS-induced genes, the LPS-induced expression of Socs-3 was significantly reduced by the treatment of RAW264.7 cells with an Atf-2 siRNA. Transcription from the Socs-3 promoter was synergistically stimulated by ATF-2 and LPS, whereas it was suppressed by Atf-2 siRNA. Histone deacetylase 1 (HDAC1) interacted with ATF-2 after LPS treatment, but not before treatment. Treatment of RAW264.7 cells with trichostatin A, an inhibitor of HDAC, suppressed the LPS-induced Socs-3 expression, suggesting that HDAC1 positively regulates the LPS-induced transcription of Socs-3. Thus, ATF-2 plays an important role in TLR-mediated transcriptional control in macrophage cells."xsd:string |
| http://purl.uniprot.org/citations/19422799 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2009.05.001"xsd:string |
| http://purl.uniprot.org/citations/19422799 | http://purl.uniprot.org/core/author | "Ishii S."xsd:string |
| http://purl.uniprot.org/citations/19422799 | http://purl.uniprot.org/core/author | "Hirose N."xsd:string |
| http://purl.uniprot.org/citations/19422799 | http://purl.uniprot.org/core/author | "Maekawa T."xsd:string |
| http://purl.uniprot.org/citations/19422799 | http://purl.uniprot.org/core/author | "Shinagawa T."xsd:string |
| http://purl.uniprot.org/citations/19422799 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19422799 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/19422799 | http://purl.uniprot.org/core/pages | "72-77"xsd:string |
| http://purl.uniprot.org/citations/19422799 | http://purl.uniprot.org/core/title | "ATF-2 regulates lipopolysaccharide-induced transcription in macrophage cells."xsd:string |
| http://purl.uniprot.org/citations/19422799 | http://purl.uniprot.org/core/volume | "385"xsd:string |
| http://purl.uniprot.org/citations/19422799 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19422799 |
| http://purl.uniprot.org/citations/19422799 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19422799 |
| http://purl.uniprot.org/uniprot/#_A2AQE9-mappedCitation-19422799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19422799 |
| http://purl.uniprot.org/uniprot/#_A2AQF0-mappedCitation-19422799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19422799 |
| http://purl.uniprot.org/uniprot/#_A2AQF1-mappedCitation-19422799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19422799 |
| http://purl.uniprot.org/uniprot/#_F6Z2B2-mappedCitation-19422799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19422799 |
| http://purl.uniprot.org/uniprot/#_G3UXC3-mappedCitation-19422799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19422799 |
| http://purl.uniprot.org/uniprot/#_O09106-mappedCitation-19422799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19422799 |
| http://purl.uniprot.org/uniprot/#_Q3UKS5-mappedCitation-19422799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19422799 |
| http://purl.uniprot.org/uniprot/#_Q3UT24-mappedCitation-19422799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19422799 |
| http://purl.uniprot.org/uniprot/#_P16951-mappedCitation-19422799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19422799 |
| http://purl.uniprot.org/uniprot/#_Q58E49-mappedCitation-19422799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19422799 |
| http://purl.uniprot.org/uniprot/#_Q8BQY2-mappedCitation-19422799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19422799 |