| http://purl.uniprot.org/citations/19423712 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19423712 | http://www.w3.org/2000/01/rdf-schema#comment | "Clarin-1 is the protein product encoded by the gene mutated in Usher syndrome III. Although the molecular function of clarin-1 is unknown, its primary structure predicts four transmembrane domains similar to a large family of membrane proteins that include tetraspanins. Here we investigated the role of clarin-1 by using heterologous expression and in vivo model systems. When expressed in HEK293 cells, clarin-1 localized to the plasma membrane and concentrated in low density compartments distinct from lipid rafts. Clarin-1 reorganized actin filament structures and induced lamellipodia. This actin-reorganizing function was absent in the modified protein encoded by the most prevalent North American Usher syndrome III mutation, the N48K form of clarin-1 deficient in N-linked glycosylation. Proteomics analyses revealed a number of clarin-1-interacting proteins involved in cell-cell adhesion, focal adhesions, cell migration, tight junctions, and regulation of the actin cytoskeleton. Consistent with the hypothesized role of clarin-1 in actin organization, F-actin-enriched stereocilia of auditory hair cells evidenced structural disorganization in Clrn1(-/-) mice. These observations suggest a possible role for clarin-1 in the regulation and homeostasis of actin filaments, and link clarin-1 to the interactive network of Usher syndrome gene products."xsd:string |
| http://purl.uniprot.org/citations/19423712 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m109.003160"xsd:string |
| http://purl.uniprot.org/citations/19423712 | http://purl.uniprot.org/core/author | "Tian G."xsd:string |
| http://purl.uniprot.org/citations/19423712 | http://purl.uniprot.org/core/author | "Zhou Y."xsd:string |
| http://purl.uniprot.org/citations/19423712 | http://purl.uniprot.org/core/author | "Palczewski K."xsd:string |
| http://purl.uniprot.org/citations/19423712 | http://purl.uniprot.org/core/author | "Miyagi M."xsd:string |
| http://purl.uniprot.org/citations/19423712 | http://purl.uniprot.org/core/author | "Geng R."xsd:string |
| http://purl.uniprot.org/citations/19423712 | http://purl.uniprot.org/core/author | "Hauswirth W.W."xsd:string |
| http://purl.uniprot.org/citations/19423712 | http://purl.uniprot.org/core/author | "Imanishi Y."xsd:string |
| http://purl.uniprot.org/citations/19423712 | http://purl.uniprot.org/core/author | "Isosomppi J."xsd:string |
| http://purl.uniprot.org/citations/19423712 | http://purl.uniprot.org/core/author | "Alagramam K.N."xsd:string |
| http://purl.uniprot.org/citations/19423712 | http://purl.uniprot.org/core/author | "Dinculescu A."xsd:string |
| http://purl.uniprot.org/citations/19423712 | http://purl.uniprot.org/core/author | "Flannery J.G."xsd:string |
| http://purl.uniprot.org/citations/19423712 | http://purl.uniprot.org/core/author | "Sankila E.M."xsd:string |
| http://purl.uniprot.org/citations/19423712 | http://purl.uniprot.org/core/author | "Hajkova D."xsd:string |
| http://purl.uniprot.org/citations/19423712 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19423712 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/19423712 | http://purl.uniprot.org/core/pages | "18980-18993"xsd:string |
| http://purl.uniprot.org/citations/19423712 | http://purl.uniprot.org/core/title | "Clarin-1, encoded by the Usher Syndrome III causative gene, forms a membranous microdomain: possible role of clarin-1 in organizing the actin cytoskeleton."xsd:string |
| http://purl.uniprot.org/citations/19423712 | http://purl.uniprot.org/core/volume | "284"xsd:string |
| http://purl.uniprot.org/citations/19423712 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19423712 |
| http://purl.uniprot.org/citations/19423712 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19423712 |
| http://purl.uniprot.org/uniprot/Q8K445#attribution-30518B2581A67CB32E11C5CFC5D25300 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19423712 |
| http://purl.uniprot.org/uniprot/Q8K445#attribution-8B6B801E7487A1FF6249DB0D92CF56CC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19423712 |