| http://purl.uniprot.org/citations/19424605 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19424605 | http://www.w3.org/2000/01/rdf-schema#comment | "The purpose of the present study was to identify genetic variants which confer susceptibility to chronic kidney disease (CKD) in high- or low-risk subjects defined by conventional risk factors separately. The study population comprised 2828 Japanese individuals, including 434 subjects with CKD [estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m(2)] and 2394 controls (eGFR > or =60 ml/min/ 1.73 m(2)). The 1012 high-risk subjects had both hypertension and diabetes mellitus, and the 1816 low-risk subjects had none of these conditions. The genotypes for 296 polymorphisms of 202 candidate genes were determined. The Chi-square test, multivariable logistic regression analysis with adjustment for covariates, as well as a stepwise forward selection procedure revealed that ten different polymorphisms were associated (P<0.05) with the prevalence of CKD in high- or low-risk subjects: the -519Aright curved arrow G polymorphism of MMP1, the 1061Aright curved arrow G (Ile405Val) polymorphism of CETP, the Aright curved arrow G (Lys45Glu) polymorphism of MMP3, the -219Gright curved arrow T polymorphism of APOE, the Aright curved arrow G (Ile1205Val) polymorphism of COL3A1, the -863Cright curved arrow A polymorphism of TNF, and the 1454Cright curved arrow G (Leu125Val) polymorphism of PECAM1 in high-risk subjects; and the 1167Cright curved arrow T (Asn389Asn) polymorphism of TGFBR2, the 2386Aright curved arrow G (Ile796Val) polymorphism of SCAP, and the TAAAright curved arrow del polymorphism of PDE4D in low-risk subjects. Among these polymorphisms, the -519Aright curved arrow G polymorphism of MMP1 and the 1167Cright curved arrow T (Asn389Asn) polymorphism of TGFBR2 were most significantly associated with CKD in high- or low-risk individuals, respectively. These results suggest that polymorphisms associated with CKD may differ among high- or low-risk subjects. Stratification of subjects according to conventional risk factors may thus be important for personalized prevention of CKD based on genetic information."xsd:string |
| http://purl.uniprot.org/citations/19424605 | http://purl.org/dc/terms/identifier | "doi:10.3892/ijmm_00000193"xsd:string |
| http://purl.uniprot.org/citations/19424605 | http://purl.uniprot.org/core/author | "Kato K."xsd:string |
| http://purl.uniprot.org/citations/19424605 | http://purl.uniprot.org/core/author | "Satoh K."xsd:string |
| http://purl.uniprot.org/citations/19424605 | http://purl.uniprot.org/core/author | "Yamada Y."xsd:string |
| http://purl.uniprot.org/citations/19424605 | http://purl.uniprot.org/core/author | "Yoshida T."xsd:string |
| http://purl.uniprot.org/citations/19424605 | http://purl.uniprot.org/core/author | "Watanabe S."xsd:string |
| http://purl.uniprot.org/citations/19424605 | http://purl.uniprot.org/core/author | "Yoshida H."xsd:string |
| http://purl.uniprot.org/citations/19424605 | http://purl.uniprot.org/core/author | "Nozawa Y."xsd:string |
| http://purl.uniprot.org/citations/19424605 | http://purl.uniprot.org/core/author | "Aoyagi Y."xsd:string |
| http://purl.uniprot.org/citations/19424605 | http://purl.uniprot.org/core/author | "Yokoi K."xsd:string |
| http://purl.uniprot.org/citations/19424605 | http://purl.uniprot.org/core/author | "Nishigaki Y."xsd:string |
| http://purl.uniprot.org/citations/19424605 | http://purl.uniprot.org/core/author | "Metoki N."xsd:string |
| http://purl.uniprot.org/citations/19424605 | http://purl.uniprot.org/core/author | "Oguri M."xsd:string |
| http://purl.uniprot.org/citations/19424605 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19424605 | http://purl.uniprot.org/core/name | "Int J Mol Med"xsd:string |
| http://purl.uniprot.org/citations/19424605 | http://purl.uniprot.org/core/pages | "785-792"xsd:string |
| http://purl.uniprot.org/citations/19424605 | http://purl.uniprot.org/core/title | "Association of gene polymorphisms with chronic kidney disease in high- or low-risk subjects defined by conventional risk factors."xsd:string |
| http://purl.uniprot.org/citations/19424605 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/19424605 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19424605 |
| http://purl.uniprot.org/citations/19424605 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19424605 |
| http://purl.uniprot.org/uniprot/#_A0A140VJR0-mappedCitation-19424605 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19424605 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3F6-mappedCitation-19424605 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19424605 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z539-mappedCitation-19424605 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19424605 |