| http://purl.uniprot.org/citations/19428111 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19428111 | http://www.w3.org/2000/01/rdf-schema#comment | "Cellular adhesion molecules involved in cell-to-cell mediated suppression by Tregs are not well characterized. We found that the majority of Tregs expressed LFA-1 but most strikingly that the frequency of Tregs in LFA-1(-/-) mice was significantly lower (approximately 50%) in the spleen, lymph nodes, and Peyer's patches compared to wild type controls. The reduction in LFA-1(-/-) Treg cells appears due in part to a reduced capacity of LFA-1(-/-) CD4(+)CD25(-) cells to be induced to become Tregs in the lymph nodes. Importantly, we found that LFA-1(-/-) Tregs fail to suppress T cell responses in vitro and have reduced function in vivo. Treg-mediated suppression does not depend on LFA-1 interactions with ICAM-1 on the surface of responder cells. Our data demonstrate that LFA-1 plays a critical role in regulatory T cell homeostasis and function."xsd:string |
| http://purl.uniprot.org/citations/19428111 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molimm.2009.04.004"xsd:string |
| http://purl.uniprot.org/citations/19428111 | http://purl.uniprot.org/core/author | "Schoeb T."xsd:string |
| http://purl.uniprot.org/citations/19428111 | http://purl.uniprot.org/core/author | "Barnum S."xsd:string |
| http://purl.uniprot.org/citations/19428111 | http://purl.uniprot.org/core/author | "Bullard D."xsd:string |
| http://purl.uniprot.org/citations/19428111 | http://purl.uniprot.org/core/author | "Wohler J."xsd:string |
| http://purl.uniprot.org/citations/19428111 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19428111 | http://purl.uniprot.org/core/name | "Mol Immunol"xsd:string |
| http://purl.uniprot.org/citations/19428111 | http://purl.uniprot.org/core/pages | "2424-2428"xsd:string |
| http://purl.uniprot.org/citations/19428111 | http://purl.uniprot.org/core/title | "LFA-1 is critical for regulatory T cell homeostasis and function."xsd:string |
| http://purl.uniprot.org/citations/19428111 | http://purl.uniprot.org/core/volume | "46"xsd:string |
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