| http://purl.uniprot.org/citations/19428459 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19428459 | http://www.w3.org/2000/01/rdf-schema#comment | "Heat shock proteins (HSPs) maintain proteostasis and may protect against age-associated pathology caused by protein malfolding. In Caenorhabditis elegans, the lifespan extension and thermotolerance in mutants with impaired insulin/IGF signals depend partly on HSP elevation. Less is known about the role of HSPs in the increased lifespan of mice with defects in GH/IGF-I pathways. We measured HSP mRNAs in liver, kidney, heart, lung, muscle and cerebral cortex from long-lived Pit1(dw/dw) Snell dwarf mice. We found many significant differences in HSP mRNA levels between dwarf and control mice, but these effects were complex and organ-specific. We noted 15 instances where HSP mRNAs were lower in Pit1(dw/dw) liver, kidney, or heart tissues, and 14/15 of these were also seen in Ghr(-/-) mice, which lack GH receptor. In contrast, of 12 examples where HSP mRNAs were higher in Snell liver, kidney, or heart, none were altered in Ghr(-/-) mice. Four liver mRNAs were depressed in both Pit1(dw/dw) and Ghr(-/-) mice, and each of these was elevated by GH injection in Ames (Prop1(df/df)) dwarf mice, consistent with the hypothesis that these declines depended on GH and/or IGF-I. Contributions of chaperones to longevity in mice may be more complex than those inferred from C. elegans."xsd:string |
| http://purl.uniprot.org/citations/19428459 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mad.2009.03.004"xsd:string |
| http://purl.uniprot.org/citations/19428459 | http://purl.uniprot.org/core/author | "Miller R.A."xsd:string |
| http://purl.uniprot.org/citations/19428459 | http://purl.uniprot.org/core/author | "Kopchick J.J."xsd:string |
| http://purl.uniprot.org/citations/19428459 | http://purl.uniprot.org/core/author | "Swindell W.R."xsd:string |
| http://purl.uniprot.org/citations/19428459 | http://purl.uniprot.org/core/author | "Conover C.A."xsd:string |
| http://purl.uniprot.org/citations/19428459 | http://purl.uniprot.org/core/author | "Bartke A."xsd:string |
| http://purl.uniprot.org/citations/19428459 | http://purl.uniprot.org/core/author | "Masternak M.M."xsd:string |
| http://purl.uniprot.org/citations/19428459 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19428459 | http://purl.uniprot.org/core/name | "Mech Ageing Dev"xsd:string |
| http://purl.uniprot.org/citations/19428459 | http://purl.uniprot.org/core/pages | "393-400"xsd:string |
| http://purl.uniprot.org/citations/19428459 | http://purl.uniprot.org/core/title | "Endocrine regulation of heat shock protein mRNA levels in long-lived dwarf mice."xsd:string |
| http://purl.uniprot.org/citations/19428459 | http://purl.uniprot.org/core/volume | "130"xsd:string |
| http://purl.uniprot.org/citations/19428459 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19428459 |
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