| http://purl.uniprot.org/citations/19428566 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19428566 | http://www.w3.org/2000/01/rdf-schema#comment | "B-1 cells are a subset of B cells responsible for the production of natural antibodies. Although the amount of natural antibody is tightly regulated, how this regulation occurs remains unknown. We examined the expression of IL-5 receptor, a cytokine receptor critical for homeostatic proliferation of B-1 cells, on B-1 cell progenitors in the fetal liver. We identified B-1 progenitors expressing low levels of IL-5 receptor alpha chain (IL-5Ralpha) and eosinophil progenitors expressing higher levels of IL-5Ralpha in the fetal liver. Moreover, the number of these B-1 progenitors were significantly reduced in the fetuses of mice deficient in Bruton's tyrosine kinase (Btk), even though IL-5 and thymic stroma lymphopoietin signaling are intact in early B lineage cells in Btk-deficient mice. These data suggest that IL-5 is possibly involved in B-1 cell development and an uncharacterized, Btk-dependent regulatory signaling pathway is involved in unexpectedly early stages of B-1 cell differentiation."xsd:string |
| http://purl.uniprot.org/citations/19428566 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.imlet.2009.03.008"xsd:string |
| http://purl.uniprot.org/citations/19428566 | http://purl.uniprot.org/core/author | "Takatsu K."xsd:string |
| http://purl.uniprot.org/citations/19428566 | http://purl.uniprot.org/core/author | "Kouro T."xsd:string |
| http://purl.uniprot.org/citations/19428566 | http://purl.uniprot.org/core/author | "Kariyone A."xsd:string |
| http://purl.uniprot.org/citations/19428566 | http://purl.uniprot.org/core/author | "Ikutani M."xsd:string |
| http://purl.uniprot.org/citations/19428566 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19428566 | http://purl.uniprot.org/core/name | "Immunol Lett"xsd:string |
| http://purl.uniprot.org/citations/19428566 | http://purl.uniprot.org/core/pages | "169-178"xsd:string |
| http://purl.uniprot.org/citations/19428566 | http://purl.uniprot.org/core/title | "Expression of IL-5Ralpha on B-1 cell progenitors in mouse fetal liver and involvement of Bruton's tyrosine kinase in their development."xsd:string |
| http://purl.uniprot.org/citations/19428566 | http://purl.uniprot.org/core/volume | "123"xsd:string |
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