| http://purl.uniprot.org/citations/19429829 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19429829 | http://www.w3.org/2000/01/rdf-schema#comment | "Cardiac L-type voltage-dependent Ca(2+) channels are heteromultimeric polypeptide complexes of alpha(1)-, alpha(2)/delta-, and beta-subunits. The alpha(2)/delta-1-subunit possesses a stereoselective, high-affinity binding site for gabapentin, widely used to treat epilepsy and postherpetic neuralgic pain as well as sleep disorders. Mutations in alpha(2)/delta-subunits of voltage-dependent Ca(2+) channels have been associated with different diseases, including epilepsy. Multiple heterologous coexpression systems have been used to study the effects of the deletion of the alpha(2)/delta-1-subunit, but attempts at a conventional knockout animal model have been ineffective. We report the development of a viable conventional knockout mouse using a construct targeting exon 2 of alpha(2)/delta-1. While the deletion of the subunit is not lethal, these animals lack high-affinity gabapentin binding sites and demonstrate a significantly decreased basal myocardial contractility and relaxation and a decreased L-type Ca(2+) current peak current amplitude. This is a novel model for studying the function of the alpha(2)/delta-1-subunit and will be of importance in the development of new pharmacological therapies."xsd:string |
| http://purl.uniprot.org/citations/19429829 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpheart.00122.2009"xsd:string |
| http://purl.uniprot.org/citations/19429829 | http://purl.uniprot.org/core/author | "Mori Y."xsd:string |
| http://purl.uniprot.org/citations/19429829 | http://purl.uniprot.org/core/author | "Ishii M."xsd:string |
| http://purl.uniprot.org/citations/19429829 | http://purl.uniprot.org/core/author | "Qin N."xsd:string |
| http://purl.uniprot.org/citations/19429829 | http://purl.uniprot.org/core/author | "Schwartz A."xsd:string |
| http://purl.uniprot.org/citations/19429829 | http://purl.uniprot.org/core/author | "Mikala G."xsd:string |
| http://purl.uniprot.org/citations/19429829 | http://purl.uniprot.org/core/author | "Varadi G."xsd:string |
| http://purl.uniprot.org/citations/19429829 | http://purl.uniprot.org/core/author | "Jones W.K."xsd:string |
| http://purl.uniprot.org/citations/19429829 | http://purl.uniprot.org/core/author | "Jordan M.A."xsd:string |
| http://purl.uniprot.org/citations/19429829 | http://purl.uniprot.org/core/author | "Zhang S.P."xsd:string |
| http://purl.uniprot.org/citations/19429829 | http://purl.uniprot.org/core/author | "Bodi I."xsd:string |
| http://purl.uniprot.org/citations/19429829 | http://purl.uniprot.org/core/author | "Flores C.M."xsd:string |
| http://purl.uniprot.org/citations/19429829 | http://purl.uniprot.org/core/author | "Varadi M."xsd:string |
| http://purl.uniprot.org/citations/19429829 | http://purl.uniprot.org/core/author | "Petrashevskaya N.N."xsd:string |
| http://purl.uniprot.org/citations/19429829 | http://purl.uniprot.org/core/author | "Koch S.E."xsd:string |
| http://purl.uniprot.org/citations/19429829 | http://purl.uniprot.org/core/author | "Muth J.N."xsd:string |
| http://purl.uniprot.org/citations/19429829 | http://purl.uniprot.org/core/author | "Kadeer N."xsd:string |
| http://purl.uniprot.org/citations/19429829 | http://purl.uniprot.org/core/author | "Fuller-Bicer G.A."xsd:string |
| http://purl.uniprot.org/citations/19429829 | http://purl.uniprot.org/core/author | "Isaacsohn I."xsd:string |
| http://purl.uniprot.org/citations/19429829 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19429829 | http://purl.uniprot.org/core/name | "Am J Physiol Heart Circ Physiol"xsd:string |
| http://purl.uniprot.org/citations/19429829 | http://purl.uniprot.org/core/pages | "H117-24"xsd:string |
| http://purl.uniprot.org/citations/19429829 | http://purl.uniprot.org/core/title | "Targeted disruption of the voltage-dependent calcium channel alpha2/delta-1-subunit."xsd:string |