| http://purl.uniprot.org/citations/19433866 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19433866 | http://www.w3.org/2000/01/rdf-schema#comment | "The induction of Rrs1 expression is one of the earliest events detected in a presymptomatic knock-in mouse model of Huntington disease (HD). Rrs1 up-regulation fulfills the HD criteria of dominance, striatal specificity, and polyglutamine dependence. Here we show that mammalian Rrs1 is localized both in the nucleolus as well as in the endoplasmic reticulum (ER) of neurons. This dual localization is shared with its newly identified molecular partner 3D3/lyric. We then show that both genes are induced by ER stress in neurons. Interestingly, we demonstrate that ER stress is an early event in a presymptomatic HD mouse model that persists throughout the life span of the rodent. We further show that ER stress also occurs in postmortem brains of HD patients."xsd:string |
| http://purl.uniprot.org/citations/19433866 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m109.018325"xsd:string |
| http://purl.uniprot.org/citations/19433866 | http://purl.uniprot.org/core/author | "MacDonald M.E."xsd:string |
| http://purl.uniprot.org/citations/19433866 | http://purl.uniprot.org/core/author | "Del Sal G."xsd:string |
| http://purl.uniprot.org/citations/19433866 | http://purl.uniprot.org/core/author | "Agostoni E."xsd:string |
| http://purl.uniprot.org/citations/19433866 | http://purl.uniprot.org/core/author | "Fossale E."xsd:string |
| http://purl.uniprot.org/citations/19433866 | http://purl.uniprot.org/core/author | "Calligaris R."xsd:string |
| http://purl.uniprot.org/citations/19433866 | http://purl.uniprot.org/core/author | "Persichetti F."xsd:string |
| http://purl.uniprot.org/citations/19433866 | http://purl.uniprot.org/core/author | "Carnemolla A."xsd:string |
| http://purl.uniprot.org/citations/19433866 | http://purl.uniprot.org/core/author | "De Maso L."xsd:string |
| http://purl.uniprot.org/citations/19433866 | http://purl.uniprot.org/core/author | "Michelazzi S."xsd:string |
| http://purl.uniprot.org/citations/19433866 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19433866 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/19433866 | http://purl.uniprot.org/core/pages | "18167-18173"xsd:string |
| http://purl.uniprot.org/citations/19433866 | http://purl.uniprot.org/core/title | "Rrs1 is involved in endoplasmic reticulum stress response in Huntington disease."xsd:string |
| http://purl.uniprot.org/citations/19433866 | http://purl.uniprot.org/core/volume | "284"xsd:string |
| http://purl.uniprot.org/citations/19433866 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19433866 |
| http://purl.uniprot.org/citations/19433866 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19433866 |
| http://purl.uniprot.org/uniprot/Q80WJ7#attribution-8A4690DCF9BC56CAAB8CE5925FF0671E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19433866 |
| http://purl.uniprot.org/uniprot/Q9CYH6#attribution-8A4690DCF9BC56CAAB8CE5925FF0671E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19433866 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BRF4-mappedCitation-19433866 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19433866 |
| http://purl.uniprot.org/uniprot/#_E9PUX0-mappedCitation-19433866 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19433866 |
| http://purl.uniprot.org/uniprot/#_F6QFT1-mappedCitation-19433866 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19433866 |
| http://purl.uniprot.org/uniprot/#_F6QHD1-mappedCitation-19433866 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19433866 |