| http://purl.uniprot.org/citations/19435791 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19435791 | http://www.w3.org/2000/01/rdf-schema#comment | "Cell adhesion molecule 1 (CADM1), an immunoglobulin superfamily member, is expressed on superior cervical ganglion neurites and mediates cell-cell adhesion by trans-homophilic binding. In addition to the membrane-bound form, we have previously shown that a soluble form (sCADM1) generated by alternative splicing possesses a stop codon immediately downstream of the immunoglobulin-like domain. Here, we demonstrate the presence of sCADM1 in vivo and its possible role in neurite extension. sCADM1 appears to be a stromal protein because extracellular-restricted, but not intracellular-restricted, anti-CADM1 antibody stained stromal protein-rich extract from mouse brains. Murine plasmacytoma cells, P3U1, were modified to secrete sCADM1 fused with either immunoglobulin (Ig)G Fc portion (sCADM1-Fc) or its deletion form that lacks the immunoglobulin-like domain (DeltasCADM1-Fc). When P3U1 derivatives expressing sCADM1-Fc or DeltasCADM1-Fc were implanted into collagen gels, Fc-fused proteins were present more abundantly around the cells. Superior cervical ganglion neurons, parental P3U1, and either derivative were implanted into collagen gels separately, and co-cultured for 4 days. Bodian staining of the gel sections revealed that most superior cervical ganglion neurites turned toward the source of sCADM1-Fc, but not DeltasCADM1-Fc. Furthermore, immunofluorescence signals for sCADM1-Fc and membrane-bound CADM1 were co-localized on the neurite surface. These results show that sCADM1 appears to be involved in directional neurite extension by serving as an anchor to which membrane-bound CADM1 on the neurites can bind."xsd:string |
| http://purl.uniprot.org/citations/19435791 | http://purl.org/dc/terms/identifier | "doi:10.2353/ajpath.2009.080743"xsd:string |
| http://purl.uniprot.org/citations/19435791 | http://purl.uniprot.org/core/author | "Ito A."xsd:string |
| http://purl.uniprot.org/citations/19435791 | http://purl.uniprot.org/core/author | "Murakami Y."xsd:string |
| http://purl.uniprot.org/citations/19435791 | http://purl.uniprot.org/core/author | "Ichiyanagi N."xsd:string |
| http://purl.uniprot.org/citations/19435791 | http://purl.uniprot.org/core/author | "Hagiyama M."xsd:string |
| http://purl.uniprot.org/citations/19435791 | http://purl.uniprot.org/core/author | "Kimura K.B."xsd:string |
| http://purl.uniprot.org/citations/19435791 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19435791 | http://purl.uniprot.org/core/name | "Am J Pathol"xsd:string |
| http://purl.uniprot.org/citations/19435791 | http://purl.uniprot.org/core/pages | "2278-2289"xsd:string |
| http://purl.uniprot.org/citations/19435791 | http://purl.uniprot.org/core/title | "Expression of a soluble isoform of cell adhesion molecule 1 in the brain and its involvement in directional neurite outgrowth."xsd:string |
| http://purl.uniprot.org/citations/19435791 | http://purl.uniprot.org/core/volume | "174"xsd:string |
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